Symptoms of Detoxification (The Herxheimer Reaction)


Glutathione is the most powerful detoxification agent produced within the human body. When we supplement with glutathione, we can increase the capacity of our body to eliminate toxins, and this can also influence our body to detoxify itself rapidly.

Rapid detoxification can result in some discomfort, which is experienced through a wide range of bodily reactions. This experience of reactions is collectively known as the Herxheimer Reaction (sometimes called a Herx Reaction, or simply Herx). The reaction is typically short lived, from a few days to at most a few weeks. This reaction includes any circumstance where the volume of toxic material exceeds the capacity of the body to eliminate it.

The primary channel of elimination within our bodies is the lymph system, which connects to every cell, working around to clock to dispose of toxins, waste, dangerous bacteria, viruses, or other microorganisms. It’s components include a vast network of vessels, nodes, and organs that circulate lymphatic fluid. This fluid (often referred to as just “lymph”), has a lot in common with blood. But unlike blood, there is no heart to pump and move the lymph. Instead, the body pressurizes the lymph vessels and pumps the fluid through the movement of muscles and joints.

The lymph system is often referred to as the garbage collector of the human body. When garbage fails to be collected or disposed of properly in society, it creates havoc and interrupts the normal flow of life. The same is true for the body. When our bodies cannot eliminate waste fast enough, the lymph system can get backed up, clogging the vessels and disrupting vital bodily functions. This is what generates the Herxheimer Reaction, and it can be experienced through a broad range of symptoms.

If anyone should experience the symptoms of a Herxheimer reaction, please don’t be alarmed. These reactions are signs that the body is hard at work cleansing itself. Some of the uncomfortable symptoms one may experience are outlined below, but they vary from person to person.

  • Headaches
  • Joint Stiffness
  • Muscle Pain
  • Cramps
  • Fatigue
  • Insomnia
  • Hyperactivity
  • Anxiety
  • Irritability
  • Fever
  • Chills or Hot Flashes
  • Bad Breath
  • Excess Bowel Movements
  • Diarrhea
  • Constipation
  • Rashes
  • Acne
  • Abnormal Heart Rate
  • Change in Blood Pressure
  • Hyperventilation
  • Swollen Glands
  • Flu-like Symptoms

The backup of lymph forces the body to take alternative, less ideal actions to remedy the excess waste. This can be helped greatly by taking proactive measures to improve the flow of lymph and reduce the severity of the reaction.

First, if the lymphatic system is overloaded, one can always reduce the amount of Nano Glutathione you are taking. This will give the body a chance to catch up. When the symptoms subside, it is possible to experiment with increasing the dosage.

Second, the lymphatic system relies upon fluidity to move. The liquid for this fluidity is pulled from the water that we drink and the food that we eat, so it is essential to drink lots of water and eat as much as possible in the way of fresh fruits and vegetables.

Third, the lymphatic system relies upon the motion and activity of the body to circulate and eliminate the waste. Exercise will force the lymph to move, and even moderate movement will help. The ideal exercise to move the lymph is a rebounder, which is similar to a trampoline. This up and down motion opens and closes the lymph nodes, and forces the fluid to move through the vessels. That may not be an option for everybody, so simply walking, running, bike-riding, swimming, or any other form of exercise will help the body out. If none of these options are available, then a massage can also be of great benefit. The majority of the lymphatic vessels are close to the surface of the skin, and the fluid can be moved through manual manipulation. This can even be done to oneself if it is not possible to procure a massage.

Fourth, rest is required. The body is working hard to detoxify itself, and this consumes a lot of energy. Paying close attention to the signals the body sends when it needs to rest is essential, along with trying to avoid stress, and performing any available relaxation techniques.

Herxheimer Reactions are typically short-lived. They can last for up to a few weeks, but they are most often resolved within the span of a few days. If you have any serious concerns about any specific reaction you may have after starting to take this product or any other product, you should consult your primary care physician. The information provided is for educational purposes and not intended to be or replace medical advice from your licensed healthcare professional.

Diet and Exercise are not the Only Factors Related to Weight Gain and Obesity


What Hollywood Stars have known for years has now been validated with new evidence from scientific research conducted at Baylor College of Medicine, that suggests as we getlolder, we getlfatter 1. Additionally other research has shown that stubbornlbellylfatlandlobesity may actually be caused by the oxidative stress that is generated as a result of toxins and free radicals produced by thelbody following chronic consumption oflsugars andlcarbohydrates 2.Research also suggests that uncontrolled buildup of these toxins and free radicals (called oxidative stress), leads to a condition where thelbody stores morelfat and uses lesslcalories makinglweightlloss much more difficult andlweightlgain much easier 2. Maybe some of you have experienced the frustration of cuttinglcalories and starting tolexercise, only to see the scale stare back at you each day not moving or even moving the wrong direction.

For many of us, including myself, the battleloflthelbulge has been a lifetime battle that I have been losing over the years. What I’ve recently learned is that the complex biochemical process that governs how muchlfat we store, how much we burn, and howlhungry we are malfunctions under heavy toxic load, making it easier to storelfat 2. When we try to startlexercising and change ourldiets, all we find is frustration because ourlbody’s natural processes aren’t functioning correctly anymore due to this high level of toxicity.

In addition to the toxic load, free radicals, and oxidative stress that is created over time by eating the wronglfoods mentioned above, artificiallsweeteners,ldietlproducts, andldiet pills all add additional toxins to the body, just pushing thelbody further out of balance and making it easier to store morelfat.

Luckily for for me and now for you, I accidentally stumbled onto a solution that helps break this cycle. This is my story of how I discovered thatlmetabolic rate andlfat storage are affected by the levels of oxidative stress 2 and free radicals and toxins left unchecked develop into this state of oxidative stress.

My Journey with Nano Glutathione

profileI initially started taking Nano Glutathione to improve my overall health and well being. Glutathione has been featured in over 89,000 studies and low glutathione has been linked to variousldiseaseslincludinglobesity,ldiabetes, heartldisease, lcancer, Alzheimer’s,lParkinson’s,lprematurelaging,lAutism, eczemalandlpsoriasis, rheumatoidlarthritis, autoimmuneldiseases, osteoporosis,lseizures and more 3-11.

I did not start taking Nano Glutathione with any specific expectation on what it might do for me, but once I realized there were some changes in mylbody, I decided to research the relationship of glutathione and this complex set of hormones that controllmetabolism,lfat storage, andlhunger in thelbody which I’ll come back to a little later, but first my incredible story.

Almost immediately after I startd taking Nano Glutathione, I noticed an increase in energy. My hair dresser even commented on the fact that I had noticeably less greylhair 12 on the sides of my head where it had been slowly taking over. My skin on my face was clearer and less puffy 13. My blood pressure went down about 10 points 14. In general I felt great.

plateauI have a regular gym schedule but had been stuck for some time atlalweight plateau. I wouldn’t say I amlfat, but I’m notlskinny either. I’ve typically always carried “alfewlextralpounds” even though I am healthy enough. Additional effort tolexercise harder or to maintain more discipline with myldiet didn’t really ever seem to produce much in the way oflfat loss and so I had just kind of resigned myself to the fact that having a few extralpounds is just what happens as youlage.

I continued with my normal gymlschedule and my normalldiet which isn’t too heavily laden with unhealthylfoods, but I wouldn’t classify as overly healthy either. During the first few weeks I wasn’t really paying that close of attention to mylbody and wasn’t really expecting any changes. One morning my partner looked at me, and said, “Baby, I think you’re finally making progress with thatldietlandlexercise routine.” This prompted me to begin my research into the role glutathione plays in thelbody.

I spent hours researching the complexities of how oxidative stress affects the metabolism and can causelweightlgain 2. Once I’d summarized my research, I shared it with Nanoceutical Solutions, the company that makes Nano Glutathione and was honored with a request by the company to share this blog article with their facebook followers and community as there are millions of people in the US struggling with the same issues of just not being able to make any progress in spite of significant changes toldietlandlexercise.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Leptin,lInsulin,lGlutathione, andlWeightlLoss

The mechanisms of how toxins and oxidative stress contribute tolweightlgain and prohibitlweightlloss are complex, and have only recently been brought to light through scientific research. The key players arelinsulin,lleptin, oxidative stress, and inflammation.

Insulinlis a hormone produced in the pancreas, and is responsible for regulating bloodlsugar and various hormones in thelbody.lInsulinlis the key that unlocks the cell, allowing the cell to absorb glucose, which comes fromlcarbohydrates in yourlfood such aslsugar andlstarches (bread,lpasta,lpotatolchips, etc). Thelglucose is then either used as energy, or converted intolfat. The morelcarbohydrates in yourlbody, the morelinsulin yourlbody will create.

leptinLeptinlis a hormone secreted bylfat cells.lLeptinlprovides feedback to your brain regarding the amount oflfat stored in yourlbody, and regulates your brain’s sense of beinglhungry. The morelfat in yourlbody, the morelleptin yourlbody will create. Also, elevatedlinsulin levels will cause the secretion of morelleptin.

Leptinlcauses oxidative stress in thelbody, which results in inflammation. This is a normal part of thelmetabolic process. As mentioned earlier, thelbody’s ability to address oxidative stress is dependent upon glutathione reserves, which are limited and decrease with age and with consumption and exposure to toxins.

Where things get out of control is during the process oflovereating, and especiallylovereating simplelcarbohydrates andlsugars.lOverconsumptionloflfood, even temporarily, causes an inflammatory state of oxidative stress in your cells that leads tolinsulin resistance, becauselinsulin cannot easily pass through a cell when it is inflamed. Yourlbody’s response to this is to create morelinsulin, which forces even morelleptin to be secreted.

The brain becomes desensitized tolleptin easily, driving ongoingloverconsumptionloflfood because the “stopleating” signal is not being received properly.lOvereatingloflcarbohydrates is especially dangerous to this process due to the relationship oflinsulin andlleptin. Carbslincreaselinsulin,linsulinlincreaseslleptinllovereating increaseslleptin, and all of this increases oxidative stress and inflammation which depletes your glutathione. To make matters worse, yourlbody’s glutathione production is reduced under high levels of oxidative stress, meaning there is less glutathione to clean out the increasing amounts of toxins and free radicals 14. You can see how this creates a nasty feedback loop that can be impossible to escape from when thelbody cannot handle the toxins and free radicals. It leads to rapidlweightlgain,lmetabolicldisorder,ldiabetes,land potentially numerous otherldiseases 15.


So how do you get out of this trap? The first step is to help yourlbody reduce the inflammation and oxidative stress, while at the same time adjusting yourldiet. In my case, I had already made adjustments to my diet and had also added moderatelexercise to my daily routine, but mylbody wasn’t responding to these changes because I had not addressed the oxidative stress and inflammation adequately. By adding Nano Glutathione to what I was already doing, I was addressing the oxidative stress in mylbody and working to clear the free radicals and toxins.

What It All Means

Even with a background in science, this is very confusing stuff and the relationships of all these hormones in thelbody are just now starting to be understood by the experts. But one thing is becoming increasingly clear. The relationship of thelmetabolism andlfatlstorage is not just a simple relationship of how manylcalories youleat and how manylcalories you should be burning. Oxidative stress and low glutathione can slow the amount oflcalories you burn and increase the amount oflcalories you store, makinglweightlgain possible even when cuttinglcalories and increasinglexercise.

Reducing inflammation and oxidative stress by increasing glutathione levels has been shown in recent research to assist thelbody in rebalancing its natural processes including thelmetaboliclrate to optimal levels 16. This means for someone like me who was making the effort toleat lesslcarbohydrates, fewerlcalories andlexercise more, that by reducing oxidative stress andlinflammation while also increasing glutathione levels, it’s possible to see improvements where they weren’t possible before.

What is Glutathione?

Glutathione is widely accepted by the medical community as a primary antioxidant and intracellular detoxification agent in thelbody. Mark Hyman, Director of Functional Medicine at the prestigious Cleveland Clinic and Medical Editor for the Huffington Post stated this about Glutathione:

“It’s the most important molecule you need to stay healthy and preventldisease — yet you’ve probably never heard of it. It’s the secret to preventlaging,lcancer,lheartldisease,ldementia and more, and necessary to treat everything fromlautism tolAlzheimer’sldisease. There are more than 89,000 medical articles about it — but your doctor doesn’t know how to address the epidemic deficiency of this critical life-giving molecule. What is it? I’m talking about the mother of all antioxidants, the master detoxifier and maestro of the immune system: GLUTATHIONE.”

The main reason you probably haven’t heard of glutathione, is that until recently direct oral supplementation was ineffective because glutathione is destroyed in the digestive tract before being absorbed 16. Consequently, increasing glutathione levels has been largely limited to expensive and painful IV treatments (over $1000 a treatment), or supplementing with oral glutathione precursors such as whey protein, NAC, cysteine, and glycine among others.


As I mentioned earlier, low glutathione levels have been linked to a large number ofldiseases includinglobesity,ldiabetes,lheartldisease, cancer,lAlzheimer’s,lParkinson’s,lprematurelaging,lAutism,leczemalandlpsoriasis,lrheumatoidlarthritis,lautoimmuneldiseases,losteoporosis,lseizureslandlmore. In addition to low glutathione being linked to variousldiseases, maintaining optimal glutathione levels has also been linked tollongevity. In a study over 5 years on healthy women between the ages of 60 and 103 found that all subjects had very high levels of glutathione in their bloodstream 17.

Why is Nano Glutathione Different?

I was one of the early recipients of this new breakthrough supplement from Nanoceutical Solutions called Nano Glutathione. This supplement uses revolutionary technology to dramatically reduce the particle size of the glutathione to 1/20,000 of normal glutathione causing an amazing absorption rate of nearly 60% within seconds of oral ingestion 18. This allows these molecules to pass straight through the lining of the mouth and directly into the bloodstream. By comparison, a study by Bastyr University Research Institute and the University of Washington on the effect of taking traditional oral glutathione found no significant changes in the biomarkers of oxidative stress, including glutathione levels 19.


Supplementing With Nano Glutathione

Nano Glutathione was made available to select participants including myself over the last few months ahead of Nanoceutical Solutions selling the product publicly. The accounts below are a few of those participant’s reports following taking Nano Glutathione.


Brad, a 43 year old from Houston, TX had been diagnosed with elevated liver enzymes and borderline high blood pressure. He received Nano Glutathione from Nanoceutical Solutions and within a month his liver enzymes had returned to normal and his bloodlpressure had returned to the normal range. He reported back his results to the company and purchased additional bottles in order to maintain optimal wellness and keep hislbody free of oxidation. During the next 4 weeks after receiving his new supply of Nano Glutathione he experienced significant changes in hislbody without changing hisldiet orlexercise routine.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Barbara, age 73 and Cliff, age 75 from Hillsboro, have been taking Nano Glutathione for the last month before this article was written. Barbara started taking Nano Glutathione with the hope it would relieve some of the memory issues she was having as she’d read thatldementia andlAlzheimer’s had been linked to oxidative stress. After just a few weeks, she reported back that her memory was much better, that she was achieving new high scores almost daily on her favorite game Word With Friends and that she was having a much easier time remembering the things she needed to do without having to retrace her steps all the time. Additionally she reported that her jointlpain had subsided significantly and most recently she reported that she had she and Cliff had experienced positivelbody changes without adding or changing anything in their routine orldiet but adding Nano Glutathione.


EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Try it For Yourself

Brad, Barbara, Cliff and I all received our Nano Glutathione direct from the manufacturer Nanoceutical Solutions. Nanoceutical Solutions manufactures their Glutathione in San Antonio, Texas in an FDA registered facility and they manufacture all their supplements with pharmaceutical grade ingredients. The company is a also a member of the BBB and they stand behind their products by offering a 90ldaylmoneylbacklguarantee on first time purchases, and al30ldaylguarantee on any repeat purchases. You can try it for yourself by clicking this link or the link below. And please come back and let us know how it worked. We’d love to share your experience. And as with all supplements, everyone is different and results may vary.

Representations regarding the efficacy and safety of Nano Glutathione have not been evaluated by thelFood and Drug Administration. The FDA only evaluateslfoods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure anyldisease. It is recommended that users follow a strictldiet andlexercise regimen to achievelweightlloss results. These products are not intended to diagnose, prevent, treat, or cure anyldisease. Click below to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of glutathione based on the expertise of relevant professionals.

  1. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione
    Dan Nguyen-Susan Samson-Vasumathi Reddy-Erica Gonzalez-Rajagopal Sekhar –
  2. Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals
    Shaimaa Ahmed-Firas Maher-Nazar Naji –
  3. Oxidative Stress and Obesity: The Chicken or the Egg?
    Annayya Aroor-Vincent DeMarco –
  4. Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients
    Dan Nguyen-Jean Hsu-Farook Jahoor-Rajagopal Sekhar –
  5. lutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori-Suzanne Krance-Sylvia Notenboom-Shujie Shi-Kim Tieu-Christine Hammond –
  6. The emerging role of glutathione in Alzheimer’s disease.
    S Saharan-P Mandal –
  7. Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine
    Rajagopal Sekhar-Siripoom McKay-Sanjeet Patel-Anuradha Guthikonda-Vasumathi Reddy-Ashok Balasubramanyam-Farook Jahoor –
  8. Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study.
    O Sendur-Y Turan-E Tastaban-C Yenisey-M Serter –
  9. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
    W Dröge-E Holm –
  10. Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes, and gastric mucosa of man.
    C Loguercio-D Taranto-L Vitale-F Beneduce-C Del –
  11. The glutathione defense system in the pathogenesis of rheumatoid arthritis.
    M Hassan-R Hadi-Z Al-Rawi-V Padron-S Stohs –
  12. Oxidative Stress in Ageing of Hair
    Ralph Trüeb –
  13. Skin anti-aging strategies
    Ruta Ganceviciene-Aikaterini Liakou-Athanasios Theodoridis-Evgenia Makrantonaki-Christos Zouboulis –
  14. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants
    Azar Baradaran-Hamid Nasri-Mahmoud Rafieian-Kopaei –
  15. Glutathione: a key player in autoimmunity.
    C Perricone-C De-R Perricone –
  16. Glutathione Depletion/Methylation Blockades in Chronic Fatigue Syndrome
    2012 4 –
  17. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.
    C Lang-B Mills-H Lang-M Liu-W Usui-J Richie-W Mastropaolo-S Murrell –
  18. Nano Glutathione Diffusion Study Results
  19. Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers
    Jason Allen-Ryan Bradley –
  20. Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging
    Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 Tweet share- Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 –



The information presented on this website is not intended as specific medicalladvice and is not a substitute for professional treatment or diagnosis. These statements have not been evaluated by thelFood and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent anyldisease.

All trademarks on this site whether registered or not are the property of their owners. The authors of this site are not sponsored or affiliated with any of the 3rd party trademark or owners and make no representation about them, their owners, products or services.

Disclosure Regarding Endorsements and Testimonials – Some of the people quoted throughout the website, whether consumers, celebrities, experts or otherwise, have benefited in some way in return for their testimonial or endorsement of the product. Many of the endorsements are simply unsolicited emails, calls or blogs from contented customers but other endorsers have received free products.

Why Do I Need Glutathione if I’m Healthy?


Through evolution, the human body has developed a variety of protective measures against the many dangers it faces from things like pathogens and toxins. Glutathione is one of the most impressive guards the body possesses. This potent antioxidant neutralizes dangerous toxins and free radicals in the body1.

Low levels of glutathione in the body have been linked to a decline in health. Conditions such as chronic fatigue2, reduced memory performance3, accelerated aging4 and many others have been linked to low glutathione.

People with certain ailments tend to be at a greater risk of glutathione deficiency and hence have the greatest need for glutathione supplementation. Diseases like AIDS5, cancer6, asthma7 and Alzheimer’s8 are almost always accompanied with significantly reduced levels of this extremely crucial antioxidant.

But What If I’m Healthy, Do I Still Need Glutathione?

Most likely, you do.

Those unhealthy individuals with low glutathione may be in more urgent need of supplementation to raise the body’s glutathione to more optimal levels.

In healthy people, glutathione deficiency may not be a problem. The body is able to naturally synthesize (produce) its own glutathione using precursors. These precursors are the amino acids L-cysteine, L-glutamic acid, and glycine.

If you are in good health, your body may be making enough glutathione to keep your various systems detoxified and well protected.


Even if you are healthy, there are many other factors that will affect glutathione production. These include genetics, your environment, diet and age.

Under perfect conditions, you wouldn’t need any supplements. Your body’s glutathione production would be enough to stabilize free radicals and eliminate heavy metals and other toxins from the body. But life is rarely perfect. There are chances that one or more factors could be limiting how much glutathione you are able to make without any supplemental assistance. The reason why many healthy people don’t think they need glutathione is because they don’t notice the symptoms when their glutathione levels are dipping.

The symptoms are mild and set in slowly to a point where you get used to feeling tired, getting sick often, having a dull skin and so on. You don’t think it’s a problem.

Although individual results vary, it is not uncommon for those with serious glutathione deficiency to experience noticeable improvements in health and well being almost immediately following starting glutathione treatment. Healthy people frequently also experience moderate changes and improvements but these may take longer to appear or remain unnoticeable.

With time however, taking glutathione can have substantial benefits. It may reduce age related symptoms, boost your immunity, reduce the risk of cancer, increase energy levels or even improve memory among many other potential benefits9.

If you are still unconvinced, here is a look at how certain factors can impact glutathione production even in otherwise healthy people.


Genetics affects everything from how you look to whether you love the taste of specific foods. Genetics also affect your health, determining whether you are at risk of certain inherited diseases and how much glutathione your body is able to make.

When it comes to genetics and glutathione, the GSS gene is the most significant. This gene is responsible for instructing cells to produce glutathione. (  Mutations in the GSS gene can cripple its ability to direct glutathione production in cells. This condition is called glutathione synthetase deficiency. It occurs in three levels: mild, moderate and severe.

While individuals with moderate and severe glutathione synthetase deficiency are at higher risk for more serious health conditions such as seizures and intellectual disability, the mild form of this deficiency does not manifest itself as noticeably.

So you could be generally healthy but still not have enough glutathione in your system to process all the free radicals causing a gradual buildup of oxidative stress. In this scenario you may gradually see an increase in You various symptoms like fatigue, insomnia, or anxiety. And unfortunately due to general aging, most people eventually reach a point where the body’s glutathione production is unable to keep up with its free radical load.

In addition to the GSS gene, a mutation in the MTHFR gene can cause a deficiency in glutathione. This gene is involved in the production of methylene-tetrahydrofolate reductase (MTHFR), an enzyme that plays an indirect role in glutathione production.

Glutathione deficiency is worse if both your parents had mutations in the GSS or MTHFR genes.

The Environment 

Toxins are all around us, from the polluted air you breathe to the sprays you use at home and even the plastics you use. Research has found that environmental toxins play a major role in the occurrence of oxidative stress. They hamper the body’s ability to produce glutathione, causing free radicals to accumulate to toxic levels.

One study showed that people living near busy roads were more likely to develop dementia compared to those living further away10

While pollutants can directly cause health problems, they may also overtax the body’s glutathione reserves, making it difficult to maintain proper cell function which can also contribute to problems like dementia.

So even if you are healthy, where you live could be a big problem. Unfortunately, this is not a factor many people are able to control. You cannot just abandon your career or business and go to the countryside.

In other cases, we get exposed to environmental toxins without being aware. Pesticides, certain utensils, fire retardants, detergents and many other common items may carry toxins that affect glutathione levels11.


All the things you were told to eat when you were a child because they were “good for you” like broccoli, spinach, kale, and the rest of the lot all result in increased glutathione production. There are a variety of other glutathione producing foods that can positively impact the body’s glutathione levels.

Conversely a diet rich in trans fats, carbohydrates, and other conventionally “unhealthy” foods can sap the body’s glutathione reserves creating additional oxidative stress.


Finally, there is the age factor. Over the years, your body continually deteriorates in function. Cells stop working as vigorously as before and various systems lose their vitality.

The aging process also affects glutathione production, reducing it at a rate of around 10% per decade after age 2012 1314.

Glutathione supplementation can mitigate the symptoms of this natural decline in production, assisting in the prevention some of the health problems associated with age related decline of glutathione.

Many people have been surprised at the health improvements they experienced after taking glutathione. We hope you’ll consider supplementing your glutathione levels with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

What are the Different Types of Glutathione Available?


You know the dangers of oxidative stress; how free radicals can damage cells and lead to an assortment of health problems such as cancer and Alzheimer’s1 2. You may also be aware that Glutathione is a powerful natural antioxidant and one of the most effective weapons against oxidative stress3 4 5.

After reading about glutathione and oxidative stress, you may decide you’d like to supplement with glutathione, but you’ll soon discover there are many different forms of Glutathione from oral to Nano Glutathione and even IV drips.

With the large number of supplements and various opinions, studies, and conflicting information, we have assembled a list of the types of glutathione we’re aware of and the pros and cons of each type to assist you in determining which type is best for you.

Nano Sublingual Glutathione

Nano glutathione delivers over 50% of each dose into the blood stream 6 approaching the effectiveness of IV treatment with the convenience of at-home use. Instead of swallowing a capsule, this moderately priced form of Glutathione involves sublingual drops which are placed under the tongue.

The sublingual drops absorb into the blood stream through the mucous membranes in your mouth.


• Over 50% of each dose absorbed into the body 6
• Convenient since you can take it at home.


• Pricier than traditional oral Glutathione (though significantly less expensive than IV Glutathione).

Traditional Oral Glutathione

Oral Glutathione supplements are one of the most popular and oldest Glutathione supplements. They come in capsule, tablet or liquid form.

But traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness. Because they have to pass through the digestive tract, very little of the original dosage survives the acidic stomach environment. What’s left is not enough to significantly increase the amount of intercellular glutathione. Thus no benefits are conferred by these supplements.


• Inexpensive.

• Can be bought over the counter and taken at home.


• Ineffective in increasing Glutathione levels.

Oral Liposomal Glutathione

To counter the disadvantages of traditional oral Glutathione supplements, researchers have come up with a new and better form of oral Glutathione. It is called Liposomal Glutathione.

Though usually taken orally, liposomal Glutathione is able to survive the journey through the gastrointestinal system and safely reach target cells.

How does it do this?

It’s all in how the dosage is transported. To design an effective transportation mechanism, experts borrowed from how substances in the body are transported. The body uses vesicles – a special sac with a fluid in it and surrounded by a fat layer – to transport materials to and from cells. The outer membrane of the vesicle is similar to a cell membrane, making it easy for the two to fuse. The vesicle is able to easily transfer its contents into the cell.

Artificial vesicles, called liposomes, work the same way. Glutathione is carried inside these tiny sacs with a lipid layer on top for protection. They also have a membrane similar to that of a cell. Thus, Liposomal Glutathione can reach target cells while still largely intact unlike traditional oral Glutathione.


• More effective than traditional oral supplements.

• Moderately priced.

• Can be taken at home.


• More expensive than traditional oral Glutathione.

• Only moderately effective raising they body’s Glutathione levels.

• Have a very short shelf life due to the Lipid layer

Acetyl Glutathione

Acetylation is a common process in medicine. It involves the addition of an acetyl group into a chemical compound. In fact, both aspirin and heroin contain acetyl. When added to oral glutathione, acetyl makes it more stable. The supplement can therefore pass through the digestive tract without undergoing the same severe degradation that traditional oral glutathione does.

Research is still ongoing on the effectiveness of Acetyl Glutathione but early studies and anecdotal evidence shows a slight increase in Glutathione levels after taking it.

As with Liposomal Glutathione, Acetyl Glutathione was developed to provide a more effective way to orally take Glutathione supplements.


• Moderately effective.

• Easy and convenient at-home use.


• More expensive than most other oral supplements mostly because of the complex production process.

• Production process requires toxic chemicals that are not natural.

Remember in order to minimize free radical production that a diet rich in fresh fruits and vegetables has been shown to be beneficial. Exercise and rest also can be beneficial. Additionally, you may consider supplementing with glutathione and to ensure optimal levels, we recommend using Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

How Do I Get More Glutathione and Why Do I Need it?


Glutathione is master antioxidant that seemingly does it all. It is a naturally occurring antioxidant and it has been shown to boost the immune system1 2 3, plays a key factor in aging4 5, heart disease6 7 and dementia8, among others. It has been shown to have some impact on cancer cells as well9. Why, then, is it not featured more prominently in discussions about health and diet?

What is Glutathione?

Glutathione is a simple molecule found in plants, animals, some fungi, bacteria and archaea. It is a combination of three protein or amino acids building blocks; cysteine, glycine and glutamine. It occurs naturally in the human body, regenerating in the liver once it is depleted, hence its reputation as the master antioxidant and the mother of all supplements. Simply, glutathione could be the most important molecule in your body.

What Does it Do?

Research has shown that keeping maintaining optimal glutathione levels can have positive effects on the body. It has also been determined that more often than not, patients with diseases such as cancer and AIDS have lower than average levels of glutathione, according to Jeremy Appleton, ND, who is the chairman and head of department of nutrition at the National College of Naturopathic Medicine in Portland, and who has done extensive research on glutathione10.

Chief among its properties is its effect as an antioxidant. It plays an active role in neutralization of free radicals. These are unstable molecules that oxidize cells (oxidation stress), leaving them unstable. Hence, it acts as a natural detoxifier, ensuring our metabolism runs properly.

It makes drugs more digestible, and more soluble for excretion. It removes other chemicals that are foreign to the body.

It works as a coenzyme in several enzymatic reactions in the body, like the chemical process in which it prevents oxidation, and how it detoxifies the body.

Glutathione is essential to the immune system; it fights disease and illness, in addition to forming red and white blood cells, keeping them healthy so they can carry out their tasks efficiently.


Different types of glutathione available

Reduced glutathione levels have been successfully linked to several health complications and even aging. It is therefore natural to want to boost your body’s glutathione concentration. As it occurs naturally in the cell, it can be difficult to find ways to get the supplement into the body. There has been discussion over the effectiveness of taking it orally, and comparisons with intravenous methods. It can be found in various states, and taken differently. For this reason, people take precursors, the molecules needed to make glutathione instead of taking glutathione directly.

Oral glutathione: taken orally, it can be very helpful in treating glaucoma, heart disease, preventing asthma and even alcoholism, cataracts, liver disease, memory loss and Alzheimer’s disease. It is debatable how fast oral intake can raise the glutathione levels in the body.

IV glutathione: Intravenous infusion of glutathione has its benefits. It is immediate, and causes no disruption in your daily activities, although it is a bit pricier. This method has been used to counter diseases like Parkinson’s.

Liposomal glutathione: this is an artificial substance that can bind to the molecule and deliver the glutathione molecule to the body. They can be effective, but they have a short shelf life, in some cases just hours, and are often foul smelling and tasting.

Acetyl glutathione: Unlike liposomal glutathione, acetyl supplements do not use a phospholipid vessel to improve absorption. It is preferable because it does not have a foul taste or smell.

Nano glutathione: this is an oral delivery system, but unlike other supplements, the glutathione is delivered by a drip method; a drop beneath the tongue where it can be absorbed through the mucous membranes of the mouth and directly enter the blood stream.

There are some foods that naturally boost glutathione production; brussel sprouts, radish, cabbage, watercress, kale and cauliflower.

Oxidative stress

When the body has an insufficient supply of glutathione to process free radicals, it creates a condition called oxidative stress. Oxidative stress refers to an imbalance between the production of free radicals and the body’s ability to effectively counteract the harmful effects of these free radicals. It is when the free radicals in the body overwhelm its ability to neutralize them.

Free radicals are produced regularly in the body, due to the reaction brought about by cells as they produce energy. Oxygen, for all its importance in the human body, aids in the formation of these free radicals. They can also be produced by external processes and factors, such as smoking. When free radicals interact with other molecules, they can cause oxidative damage to the membranes, proteins and genes. Studies have heavily linked oxidative damage with many diseases like cancer, chronic fatigue syndrome, diabetes, anxiety and even the aging process.

The body is therefore forced to produce antioxidants to prevent this damage. Antioxidants suppress or eliminate these free radicals. Typically, it cannot produce enough antioxidants to get rid of all the free radicals. This is where diet and healthy living come in; you can help your body by increasing the level of antioxidants available to defend itself. This can be done by consuming foods rich in antioxidants, or taking supplements that boost your antioxidant levels.

Foods you can take are those rich in vitamins, particularly Vitamin C and E which assist the body in recycling its own glutathione capacity. These include vegetables and fruits like tomatoes, oranges, grapefruit, lemons and limes, spinach, asparagus, walnuts. Where you can, stick to organic foods. Avoid sugar and processed foods, as these increase the toxins in your system. Other toxins include alcohol and cigarettes.

Glutathione works well as an antioxidant due to its Sulfur content. Take foods rich in sulfur as well; garlic, cabbage, collard greens, broccoli and onions.

Oxidative stress can result from physical or emotional stress also. Fatigue, headaches and muscle pains are a few of the symptoms that can indicate oxidative stress. It will help to avoid stressful situations. Exercise also helps build up the immune system and facilitates the production of glutathione.

It is equally effective to increase the body’s antioxidant levels by supplementing the body’s natural production capacity to clear the oxidative stress. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.