Symptoms of Detoxification (The Herxheimer Reaction)

cellular_detox

Glutathione is the most powerful detoxification agent produced within the human body. When we supplement with glutathione, we can increase the capacity of our body to eliminate toxins, and this can also influence our body to detoxify itself rapidly.

Rapid detoxification can result in some discomfort, which is experienced through a wide range of bodily reactions. This experience of reactions is collectively known as the Herxheimer Reaction (sometimes called a Herx Reaction, or simply Herx). The reaction is typically short lived, from a few days to at most a few weeks. This reaction includes any circumstance where the volume of toxic material exceeds the capacity of the body to eliminate it.

The primary channel of elimination within our bodies is the lymph system, which connects to every cell, working around to clock to dispose of toxins, waste, dangerous bacteria, viruses, or other microorganisms. It’s components include a vast network of vessels, nodes, and organs that circulate lymphatic fluid. This fluid (often referred to as just “lymph”), has a lot in common with blood. But unlike blood, there is no heart to pump and move the lymph. Instead, the body pressurizes the lymph vessels and pumps the fluid through the movement of muscles and joints.

The lymph system is often referred to as the garbage collector of the human body. When garbage fails to be collected or disposed of properly in society, it creates havoc and interrupts the normal flow of life. The same is true for the body. When our bodies cannot eliminate waste fast enough, the lymph system can get backed up, clogging the vessels and disrupting vital bodily functions. This is what generates the Herxheimer Reaction, and it can be experienced through a broad range of symptoms.

If anyone should experience the symptoms of a Herxheimer reaction, please don’t be alarmed. These reactions are signs that the body is hard at work cleansing itself. Some of the uncomfortable symptoms one may experience are outlined below, but they vary from person to person.

  • Headaches
  • Joint Stiffness
  • Muscle Pain
  • Cramps
  • Fatigue
  • Insomnia
  • Hyperactivity
  • Anxiety
  • Irritability
  • Fever
  • Chills or Hot Flashes
  • Bad Breath
  • Excess Bowel Movements
  • Diarrhea
  • Constipation
  • Rashes
  • Acne
  • Abnormal Heart Rate
  • Change in Blood Pressure
  • Hyperventilation
  • Swollen Glands
  • Flu-like Symptoms

The backup of lymph forces the body to take alternative, less ideal actions to remedy the excess waste. This can be helped greatly by taking proactive measures to improve the flow of lymph and reduce the severity of the reaction.

First, if the lymphatic system is overloaded, one can always reduce the amount of Nano Glutathione you are taking. This will give the body a chance to catch up. When the symptoms subside, it is possible to experiment with increasing the dosage.

Second, the lymphatic system relies upon fluidity to move. The liquid for this fluidity is pulled from the water that we drink and the food that we eat, so it is essential to drink lots of water and eat as much as possible in the way of fresh fruits and vegetables.

Third, the lymphatic system relies upon the motion and activity of the body to circulate and eliminate the waste. Exercise will force the lymph to move, and even moderate movement will help. The ideal exercise to move the lymph is a rebounder, which is similar to a trampoline. This up and down motion opens and closes the lymph nodes, and forces the fluid to move through the vessels. That may not be an option for everybody, so simply walking, running, bike-riding, swimming, or any other form of exercise will help the body out. If none of these options are available, then a massage can also be of great benefit. The majority of the lymphatic vessels are close to the surface of the skin, and the fluid can be moved through manual manipulation. This can even be done to oneself if it is not possible to procure a massage.

Fourth, rest is required. The body is working hard to detoxify itself, and this consumes a lot of energy. Paying close attention to the signals the body sends when it needs to rest is essential, along with trying to avoid stress, and performing any available relaxation techniques.

Herxheimer Reactions are typically short-lived. They can last for up to a few weeks, but they are most often resolved within the span of a few days. If you have any serious concerns about any specific reaction you may have after starting to take this product or any other product, you should consult your primary care physician. The information provided is for educational purposes and not intended to be or replace medical advice from your licensed healthcare professional.

Diet and Exercise are not the Only Factors Related to Weight Gain and Obesity

hero-diet

What Hollywood Stars have known for years has now been validated with new evidence from scientific research conducted at Baylor College of Medicine, that suggests as we getlolder, we getlfatter 1. Additionally other research has shown that stubbornlbellylfatlandlobesity may actually be caused by the oxidative stress that is generated as a result of toxins and free radicals produced by thelbody following chronic consumption oflsugars andlcarbohydrates 2.Research also suggests that uncontrolled buildup of these toxins and free radicals (called oxidative stress), leads to a condition where thelbody stores morelfat and uses lesslcalories makinglweightlloss much more difficult andlweightlgain much easier 2. Maybe some of you have experienced the frustration of cuttinglcalories and starting tolexercise, only to see the scale stare back at you each day not moving or even moving the wrong direction.

For many of us, including myself, the battleloflthelbulge has been a lifetime battle that I have been losing over the years. What I’ve recently learned is that the complex biochemical process that governs how muchlfat we store, how much we burn, and howlhungry we are malfunctions under heavy toxic load, making it easier to storelfat 2. When we try to startlexercising and change ourldiets, all we find is frustration because ourlbody’s natural processes aren’t functioning correctly anymore due to this high level of toxicity.

In addition to the toxic load, free radicals, and oxidative stress that is created over time by eating the wronglfoods mentioned above, artificiallsweeteners,ldietlproducts, andldiet pills all add additional toxins to the body, just pushing thelbody further out of balance and making it easier to store morelfat.

Luckily for for me and now for you, I accidentally stumbled onto a solution that helps break this cycle. This is my story of how I discovered thatlmetabolic rate andlfat storage are affected by the levels of oxidative stress 2 and free radicals and toxins left unchecked develop into this state of oxidative stress.

My Journey with Nano Glutathione

profileI initially started taking Nano Glutathione to improve my overall health and well being. Glutathione has been featured in over 89,000 studies and low glutathione has been linked to variousldiseaseslincludinglobesity,ldiabetes, heartldisease, lcancer, Alzheimer’s,lParkinson’s,lprematurelaging,lAutism, eczemalandlpsoriasis, rheumatoidlarthritis, autoimmuneldiseases, osteoporosis,lseizures and more 3-11.

I did not start taking Nano Glutathione with any specific expectation on what it might do for me, but once I realized there were some changes in mylbody, I decided to research the relationship of glutathione and this complex set of hormones that controllmetabolism,lfat storage, andlhunger in thelbody which I’ll come back to a little later, but first my incredible story.

Almost immediately after I startd taking Nano Glutathione, I noticed an increase in energy. My hair dresser even commented on the fact that I had noticeably less greylhair 12 on the sides of my head where it had been slowly taking over. My skin on my face was clearer and less puffy 13. My blood pressure went down about 10 points 14. In general I felt great.

plateauI have a regular gym schedule but had been stuck for some time atlalweight plateau. I wouldn’t say I amlfat, but I’m notlskinny either. I’ve typically always carried “alfewlextralpounds” even though I am healthy enough. Additional effort tolexercise harder or to maintain more discipline with myldiet didn’t really ever seem to produce much in the way oflfat loss and so I had just kind of resigned myself to the fact that having a few extralpounds is just what happens as youlage.

I continued with my normal gymlschedule and my normalldiet which isn’t too heavily laden with unhealthylfoods, but I wouldn’t classify as overly healthy either. During the first few weeks I wasn’t really paying that close of attention to mylbody and wasn’t really expecting any changes. One morning my partner looked at me, and said, “Baby, I think you’re finally making progress with thatldietlandlexercise routine.” This prompted me to begin my research into the role glutathione plays in thelbody.

I spent hours researching the complexities of how oxidative stress affects the metabolism and can causelweightlgain 2. Once I’d summarized my research, I shared it with Nanoceutical Solutions, the company that makes Nano Glutathione and was honored with a request by the company to share this blog article with their facebook followers and community as there are millions of people in the US struggling with the same issues of just not being able to make any progress in spite of significant changes toldietlandlexercise.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Leptin,lInsulin,lGlutathione, andlWeightlLoss

The mechanisms of how toxins and oxidative stress contribute tolweightlgain and prohibitlweightlloss are complex, and have only recently been brought to light through scientific research. The key players arelinsulin,lleptin, oxidative stress, and inflammation.

Insulinlis a hormone produced in the pancreas, and is responsible for regulating bloodlsugar and various hormones in thelbody.lInsulinlis the key that unlocks the cell, allowing the cell to absorb glucose, which comes fromlcarbohydrates in yourlfood such aslsugar andlstarches (bread,lpasta,lpotatolchips, etc). Thelglucose is then either used as energy, or converted intolfat. The morelcarbohydrates in yourlbody, the morelinsulin yourlbody will create.

leptinLeptinlis a hormone secreted bylfat cells.lLeptinlprovides feedback to your brain regarding the amount oflfat stored in yourlbody, and regulates your brain’s sense of beinglhungry. The morelfat in yourlbody, the morelleptin yourlbody will create. Also, elevatedlinsulin levels will cause the secretion of morelleptin.

Leptinlcauses oxidative stress in thelbody, which results in inflammation. This is a normal part of thelmetabolic process. As mentioned earlier, thelbody’s ability to address oxidative stress is dependent upon glutathione reserves, which are limited and decrease with age and with consumption and exposure to toxins.

Where things get out of control is during the process oflovereating, and especiallylovereating simplelcarbohydrates andlsugars.lOverconsumptionloflfood, even temporarily, causes an inflammatory state of oxidative stress in your cells that leads tolinsulin resistance, becauselinsulin cannot easily pass through a cell when it is inflamed. Yourlbody’s response to this is to create morelinsulin, which forces even morelleptin to be secreted.

The brain becomes desensitized tolleptin easily, driving ongoingloverconsumptionloflfood because the “stopleating” signal is not being received properly.lOvereatingloflcarbohydrates is especially dangerous to this process due to the relationship oflinsulin andlleptin. Carbslincreaselinsulin,linsulinlincreaseslleptinllovereating increaseslleptin, and all of this increases oxidative stress and inflammation which depletes your glutathione. To make matters worse, yourlbody’s glutathione production is reduced under high levels of oxidative stress, meaning there is less glutathione to clean out the increasing amounts of toxins and free radicals 14. You can see how this creates a nasty feedback loop that can be impossible to escape from when thelbody cannot handle the toxins and free radicals. It leads to rapidlweightlgain,lmetabolicldisorder,ldiabetes,land potentially numerous otherldiseases 15.

oxidative-stress

So how do you get out of this trap? The first step is to help yourlbody reduce the inflammation and oxidative stress, while at the same time adjusting yourldiet. In my case, I had already made adjustments to my diet and had also added moderatelexercise to my daily routine, but mylbody wasn’t responding to these changes because I had not addressed the oxidative stress and inflammation adequately. By adding Nano Glutathione to what I was already doing, I was addressing the oxidative stress in mylbody and working to clear the free radicals and toxins.

What It All Means

Even with a background in science, this is very confusing stuff and the relationships of all these hormones in thelbody are just now starting to be understood by the experts. But one thing is becoming increasingly clear. The relationship of thelmetabolism andlfatlstorage is not just a simple relationship of how manylcalories youleat and how manylcalories you should be burning. Oxidative stress and low glutathione can slow the amount oflcalories you burn and increase the amount oflcalories you store, makinglweightlgain possible even when cuttinglcalories and increasinglexercise.

Reducing inflammation and oxidative stress by increasing glutathione levels has been shown in recent research to assist thelbody in rebalancing its natural processes including thelmetaboliclrate to optimal levels 16. This means for someone like me who was making the effort toleat lesslcarbohydrates, fewerlcalories andlexercise more, that by reducing oxidative stress andlinflammation while also increasing glutathione levels, it’s possible to see improvements where they weren’t possible before.

What is Glutathione?

Glutathione is widely accepted by the medical community as a primary antioxidant and intracellular detoxification agent in thelbody. Mark Hyman, Director of Functional Medicine at the prestigious Cleveland Clinic and Medical Editor for the Huffington Post stated this about Glutathione:

“It’s the most important molecule you need to stay healthy and preventldisease — yet you’ve probably never heard of it. It’s the secret to preventlaging,lcancer,lheartldisease,ldementia and more, and necessary to treat everything fromlautism tolAlzheimer’sldisease. There are more than 89,000 medical articles about it — but your doctor doesn’t know how to address the epidemic deficiency of this critical life-giving molecule. What is it? I’m talking about the mother of all antioxidants, the master detoxifier and maestro of the immune system: GLUTATHIONE.”

The main reason you probably haven’t heard of glutathione, is that until recently direct oral supplementation was ineffective because glutathione is destroyed in the digestive tract before being absorbed 16. Consequently, increasing glutathione levels has been largely limited to expensive and painful IV treatments (over $1000 a treatment), or supplementing with oral glutathione precursors such as whey protein, NAC, cysteine, and glycine among others.

body

As I mentioned earlier, low glutathione levels have been linked to a large number ofldiseases includinglobesity,ldiabetes,lheartldisease, cancer,lAlzheimer’s,lParkinson’s,lprematurelaging,lAutism,leczemalandlpsoriasis,lrheumatoidlarthritis,lautoimmuneldiseases,losteoporosis,lseizureslandlmore. In addition to low glutathione being linked to variousldiseases, maintaining optimal glutathione levels has also been linked tollongevity. In a study over 5 years on healthy women between the ages of 60 and 103 found that all subjects had very high levels of glutathione in their bloodstream 17.

Why is Nano Glutathione Different?

I was one of the early recipients of this new breakthrough supplement from Nanoceutical Solutions called Nano Glutathione. This supplement uses revolutionary technology to dramatically reduce the particle size of the glutathione to 1/20,000 of normal glutathione causing an amazing absorption rate of nearly 60% within seconds of oral ingestion 18. This allows these molecules to pass straight through the lining of the mouth and directly into the bloodstream. By comparison, a study by Bastyr University Research Institute and the University of Washington on the effect of taking traditional oral glutathione found no significant changes in the biomarkers of oxidative stress, including glutathione levels 19.

delivery

Supplementing With Nano Glutathione

Nano Glutathione was made available to select participants including myself over the last few months ahead of Nanoceutical Solutions selling the product publicly. The accounts below are a few of those participant’s reports following taking Nano Glutathione.

brad

Brad, a 43 year old from Houston, TX had been diagnosed with elevated liver enzymes and borderline high blood pressure. He received Nano Glutathione from Nanoceutical Solutions and within a month his liver enzymes had returned to normal and his bloodlpressure had returned to the normal range. He reported back his results to the company and purchased additional bottles in order to maintain optimal wellness and keep hislbody free of oxidation. During the next 4 weeks after receiving his new supply of Nano Glutathione he experienced significant changes in hislbody without changing hisldiet orlexercise routine.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Barbara, age 73 and Cliff, age 75 from Hillsboro, have been taking Nano Glutathione for the last month before this article was written. Barbara started taking Nano Glutathione with the hope it would relieve some of the memory issues she was having as she’d read thatldementia andlAlzheimer’s had been linked to oxidative stress. After just a few weeks, she reported back that her memory was much better, that she was achieving new high scores almost daily on her favorite game Word With Friends and that she was having a much easier time remembering the things she needed to do without having to retrace her steps all the time. Additionally she reported that her jointlpain had subsided significantly and most recently she reported that she had she and Cliff had experienced positivelbody changes without adding or changing anything in their routine orldiet but adding Nano Glutathione.

barbara

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Try it For Yourself

Brad, Barbara, Cliff and I all received our Nano Glutathione direct from the manufacturer Nanoceutical Solutions. Nanoceutical Solutions manufactures their Glutathione in San Antonio, Texas in an FDA registered facility and they manufacture all their supplements with pharmaceutical grade ingredients. The company is a also a member of the BBB and they stand behind their products by offering a 90ldaylmoneylbacklguarantee on first time purchases, and al30ldaylguarantee on any repeat purchases. You can try it for yourself by clicking this link or the link below. And please come back and let us know how it worked. We’d love to share your experience. And as with all supplements, everyone is different and results may vary.

Representations regarding the efficacy and safety of Nano Glutathione have not been evaluated by thelFood and Drug Administration. The FDA only evaluateslfoods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure anyldisease. It is recommended that users follow a strictldiet andlexercise regimen to achievelweightlloss results. These products are not intended to diagnose, prevent, treat, or cure anyldisease. Click below to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of glutathione based on the expertise of relevant professionals.

  1. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione
    Dan Nguyen-Susan Samson-Vasumathi Reddy-Erica Gonzalez-Rajagopal Sekhar – http://onlinelibrary.wiley.com/doi/10.1111/acel.12073/abstract
  2. Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals
    Shaimaa Ahmed-Firas Maher-Nazar Naji – https://www.omicsonline.org/open-access/effect-of-leptin-and-oxidative-stress-in-the-blood-of-obese-individuals-2161-1009-1000288.php?aid=80393&view=mobile
  3. Oxidative Stress and Obesity: The Chicken or the Egg?
    Annayya Aroor-Vincent DeMarco – http://diabetes.diabetesjournals.org/content/63/7/2216
  4. Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients
    Dan Nguyen-Jean Hsu-Farook Jahoor-Rajagopal Sekhar – http://press.endocrine.org/doi/abs/10.1210/jc.2013-2376
  5. lutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori-Suzanne Krance-Sylvia Notenboom-Shujie Shi-Kim Tieu-Christine Hammond – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/
  6. The emerging role of glutathione in Alzheimer’s disease.
    S Saharan-P Mandal – https://www.ncbi.nlm.nih.gov/pubmed/24496077
  7. Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine
    Rajagopal Sekhar-Siripoom McKay-Sanjeet Patel-Anuradha Guthikonda-Vasumathi Reddy-Ashok Balasubramanyam-Farook Jahoor – http://care.diabetesjournals.org/content/34/1/162
  8. Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study.
    O Sendur-Y Turan-E Tastaban-C Yenisey-M Serter – http://www.ncbi.nlm.nih.gov/pubmed/18853166
  9. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
    W Dröge-E Holm – http://www.ncbi.nlm.nih.gov/pubmed/9367343
  10. Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes, and gastric mucosa of man.
    C Loguercio-D Taranto-L Vitale-F Beneduce-C Del – http://www.ncbi.nlm.nih.gov/pubmed/8720922
  11. The glutathione defense system in the pathogenesis of rheumatoid arthritis.
    M Hassan-R Hadi-Z Al-Rawi-V Padron-S Stohs – http://www.ncbi.nlm.nih.gov/pubmed/11180282
  12. Oxidative Stress in Ageing of Hair
    Ralph Trüeb – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929555/
  13. Skin anti-aging strategies
    Ruta Ganceviciene-Aikaterini Liakou-Athanasios Theodoridis-Evgenia Makrantonaki-Christos Zouboulis – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
  14. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants
    Azar Baradaran-Hamid Nasri-Mahmoud Rafieian-Kopaei – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115353/
  15. Glutathione: a key player in autoimmunity.
    C Perricone-C De-R Perricone – http://www.ncbi.nlm.nih.gov/pubmed/19393193
  16. Glutathione Depletion/Methylation Blockades in Chronic Fatigue Syndrome
    2012 4 – http://phoenixrising.me/research-2/glutathione-depletionmethylation-blockades-in-chronic-fatigue-syndrome/glutathione-depletion-methylation-cycle-block-a-hypothesis-for-the-pathogenesis-of-chronic-fatigue-syndrome-by-richard-a-van-konynenbury-ph-d
  17. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.
    C Lang-B Mills-H Lang-M Liu-W Usui-J Richie-W Mastropaolo-S Murrell – https://www.ncbi.nlm.nih.gov/pubmed/12486409
  18. Nano Glutathione Diffusion Study Results
    https://www.nanoceuticalsolutions.com/wp-content/uploads/2016/06/Nano-Glutathione-Drug-Diffususion-Study-Results.pdf
  19. Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers
    Jason Allen-Ryan Bradley – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162377/
  20. Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging
    Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 Tweet share- Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 – https://www.bcm.edu/news/geriatrics/glutathione-deficiency-fat-insulin-aging

Sources

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The information presented on this website is not intended as specific medicalladvice and is not a substitute for professional treatment or diagnosis. These statements have not been evaluated by thelFood and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent anyldisease.

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Disclosure Regarding Endorsements and Testimonials – Some of the people quoted throughout the website, whether consumers, celebrities, experts or otherwise, have benefited in some way in return for their testimonial or endorsement of the product. Many of the endorsements are simply unsolicited emails, calls or blogs from contented customers but other endorsers have received free products.

Why Do I Need Glutathione if I’m Healthy?

healthy-life

Through evolution, the human body has developed a variety of protective measures against the many dangers it faces from things like pathogens and toxins. Glutathione is one of the most impressive guards the body possesses. This potent antioxidant neutralizes dangerous toxins and free radicals in the body1.

Low levels of glutathione in the body have been linked to a decline in health. Conditions such as chronic fatigue2, reduced memory performance3, accelerated aging4 and many others have been linked to low glutathione.

People with certain ailments tend to be at a greater risk of glutathione deficiency and hence have the greatest need for glutathione supplementation. Diseases like AIDS5, cancer6, asthma7 and Alzheimer’s8 are almost always accompanied with significantly reduced levels of this extremely crucial antioxidant.

But What If I’m Healthy, Do I Still Need Glutathione?

Most likely, you do.

Those unhealthy individuals with low glutathione may be in more urgent need of supplementation to raise the body’s glutathione to more optimal levels.

In healthy people, glutathione deficiency may not be a problem. The body is able to naturally synthesize (produce) its own glutathione using precursors. These precursors are the amino acids L-cysteine, L-glutamic acid, and glycine.

If you are in good health, your body may be making enough glutathione to keep your various systems detoxified and well protected.

But…

Even if you are healthy, there are many other factors that will affect glutathione production. These include genetics, your environment, diet and age.

Under perfect conditions, you wouldn’t need any supplements. Your body’s glutathione production would be enough to stabilize free radicals and eliminate heavy metals and other toxins from the body. But life is rarely perfect. There are chances that one or more factors could be limiting how much glutathione you are able to make without any supplemental assistance. The reason why many healthy people don’t think they need glutathione is because they don’t notice the symptoms when their glutathione levels are dipping.

The symptoms are mild and set in slowly to a point where you get used to feeling tired, getting sick often, having a dull skin and so on. You don’t think it’s a problem.

Although individual results vary, it is not uncommon for those with serious glutathione deficiency to experience noticeable improvements in health and well being almost immediately following starting glutathione treatment. Healthy people frequently also experience moderate changes and improvements but these may take longer to appear or remain unnoticeable.

With time however, taking glutathione can have substantial benefits. It may reduce age related symptoms, boost your immunity, reduce the risk of cancer, increase energy levels or even improve memory among many other potential benefits9.

If you are still unconvinced, here is a look at how certain factors can impact glutathione production even in otherwise healthy people.

Genetics 

Genetics affects everything from how you look to whether you love the taste of specific foods. Genetics also affect your health, determining whether you are at risk of certain inherited diseases and how much glutathione your body is able to make.

When it comes to genetics and glutathione, the GSS gene is the most significant. This gene is responsible for instructing cells to produce glutathione. (https://ghr.nlm.nih.gov/gene/GSS#)  Mutations in the GSS gene can cripple its ability to direct glutathione production in cells. This condition is called glutathione synthetase deficiency. It occurs in three levels: mild, moderate and severe.

While individuals with moderate and severe glutathione synthetase deficiency are at higher risk for more serious health conditions such as seizures and intellectual disability, the mild form of this deficiency does not manifest itself as noticeably.

So you could be generally healthy but still not have enough glutathione in your system to process all the free radicals causing a gradual buildup of oxidative stress. In this scenario you may gradually see an increase in You various symptoms like fatigue, insomnia, or anxiety. And unfortunately due to general aging, most people eventually reach a point where the body’s glutathione production is unable to keep up with its free radical load.

In addition to the GSS gene, a mutation in the MTHFR gene can cause a deficiency in glutathione. This gene is involved in the production of methylene-tetrahydrofolate reductase (MTHFR), an enzyme that plays an indirect role in glutathione production.

Glutathione deficiency is worse if both your parents had mutations in the GSS or MTHFR genes.

The Environment 

Toxins are all around us, from the polluted air you breathe to the sprays you use at home and even the plastics you use. Research has found that environmental toxins play a major role in the occurrence of oxidative stress. They hamper the body’s ability to produce glutathione, causing free radicals to accumulate to toxic levels.

One study showed that people living near busy roads were more likely to develop dementia compared to those living further away10

While pollutants can directly cause health problems, they may also overtax the body’s glutathione reserves, making it difficult to maintain proper cell function which can also contribute to problems like dementia.

So even if you are healthy, where you live could be a big problem. Unfortunately, this is not a factor many people are able to control. You cannot just abandon your career or business and go to the countryside.

In other cases, we get exposed to environmental toxins without being aware. Pesticides, certain utensils, fire retardants, detergents and many other common items may carry toxins that affect glutathione levels11.

Diet

All the things you were told to eat when you were a child because they were “good for you” like broccoli, spinach, kale, and the rest of the lot all result in increased glutathione production. There are a variety of other glutathione producing foods that can positively impact the body’s glutathione levels.

Conversely a diet rich in trans fats, carbohydrates, and other conventionally “unhealthy” foods can sap the body’s glutathione reserves creating additional oxidative stress.

Age

Finally, there is the age factor. Over the years, your body continually deteriorates in function. Cells stop working as vigorously as before and various systems lose their vitality.

The aging process also affects glutathione production, reducing it at a rate of around 10% per decade after age 2012 1314.

Glutathione supplementation can mitigate the symptoms of this natural decline in production, assisting in the prevention some of the health problems associated with age related decline of glutathione.

Many people have been surprised at the health improvements they experienced after taking glutathione. We hope you’ll consider supplementing your glutathione levels with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

What is Oxidative Stress and What Can You Do to Prevent It?

oxidative-stress

Growing up, we are taught about the crucial role oxygen plays on earth. The most important thing we learn is that we cannot breathe without it. Oxygen is life, essentially. A bit later on we also learn that it is important for many processes such as burning and growth.

But did you know that the same life-sustaining oxygen also is the fundamental cause of aging? Oxygen causes oxidation when it combines with certain other elements. This same process can be seen outside the body when steel (iron) rusts or a banana turns brown after being unwrapped and exposed to the air.

Within the body, oxidation is known as oxidative stress and it can also lead to adverse health conditions including cancer1, dementia2, heart failure3 and chronic fatigue syndrome4 among others.

How can such an essential and beneficial substance case all this? The answer is in a scientific term known as Oxidative Stress.

Oxidative stress is the result of certain oxygen byproducts gone rogue. You see, oxygen is used in the body for various processes including metabolism and energy synthesis.

In any chemical process, there have to be byproducts. In addition to releasing mostly harmless byproducts, these oxygen-fueled reactions also release ‘incomplete’ atoms and molecules called free radicals. I say incomplete because they have an unpaired electron.

Hence, they are actively seeking for that electron to complete them. This makes them highly reactive and unstable. They are essentially looking for anything they can react with so as to gain the extra electron and achieve stability.

How Free Radicals Affect the Body and the Body’s Response 

In their quest for stability, free radicals may react with parts of body cells including cell membranes, DNA and proteins. This reaction is known as oxidation. It is the same reaction that causes an exposed apple to turn brown or a piece of metal to rust.

By ‘stealing’ an electron from a cell, a free radical causes damage to that cell, causing it to function defectively. If the damage is extensive, the cell dies.

Now imagine many free radicals attacking many cells in the body. They can cause a lot of havoc. But the body is not without defense. It responds by releasing antioxidants. These are compounds that reduce damage to cells by preventing the formation of free radicals or reacting with them before they can cause damage.

Antioxidants neutralize free radicals by donating one of their electrons without themselves getting unstable. Once stabilized, the free radical is no longer a danger to cells.

How Oxidative Stress Occurs

It is not always that there are enough antioxidants to combat and neutralize free radicals. If the free radicals overwhelm available antioxidants, oxidative stress follows.

This is essentially an imbalance between the number of free radicals and the body’s ability to fend them off using antioxidants. In such a case, free radicals are free to continue their rampage of body cells. As they react with cells and take electrons, they rob crucial components from them. Cell function is severely hampered or completely stopped.

Consequences of Oxidative Stress 

When the body is unable to cope with the number of free radicals, it results in health deterioration as cells lose their vitality and some die.

This can damage major organs such as the kidney, heart and lungs5. It can also affect major functions within the body including digestion and immunity6. Here are some of the possible consequences of oxidative stress.

• Kidney disease7 8.

• Auto immune diseases 9 10.

• Heart disease. This leading killer develops after arteries in the heart harden and narrow in a process called atherosclerosis. A reaction between free radicals and bad cholesterol has been linked to this process. It has been discovered that people who have low antioxidant intake tend to be at the highest risk of heart disease11.

• Joint inflammation leading to conditions such as arthritis12.

• Problems with the digestive system resulting in conditions such as inflammatory bowel disorder13 14.

• Cell damage and death in the brain causes a deterioration of brain health and function. This causes Alzheimer’s, Parkinson’s, Huntington’s disease and other forms of dementia. Oxidative stress has been suggested as one of the main contributors to brain aging15.

• Skin damage. Free radicals can also target skin cells. This compromises major skin functions including UV protection. With continued assault from these reactive molecules, the skin shows accelerated signs of aging. In fact, the Free-radical theory of aging suggests that oxidative stress is the main reason why humans grow old16.

• Apart from causing the skin to age, oxidative stress can also lead to other skin conditions including lesions, scarring and overall skin damage17.

• Cancer. For decades, cancer has stumped researchers with a cure still eluding them. In their study of how it comes about, free radicals have been singled out as major suspects17 18 19. Remember cancer is basically caused by malfunctioning cells. Also remember that free radicals damages cells, affecting how they function. You can see how the two connect.

• Lung disorders. Pollutants in the air can increase the amount of free radicals in the lungs, causing oxidative stress as antioxidants are unable to cope. This could lead to various lung diseases including asthma 20 and lung cancer21.

Symptoms of Oxidative Stress 

There are certain symptoms that signal oxidative stress. They include chronic fatigue4, muscle or joint pain22, memory loss1, unusually early signs of aging such as greyed hair and wrinkles23, decreased eye sight24 as the eye lenses are damaged and increased susceptibility to infections as your immune system is compromised.

Dealing With Oxidative Stress 

Combating oxidative stress is all about returning the balance between free radicals and antioxidants. One way to do this is to make sure the body has access to adequate antioxidants. This involves eating a proper diet with plenty of fruits and vegetables, taking supplements and sleeping well.

Dieting and supplements are especially important as they directly increase the number of antioxidants in the body. Some of the best foods include tomatoes, spinach, walnuts, onions and avocados. These foods supply important antioxidants such as glutathione and vitamin C.

As you add more antioxidants, you also need to take action to prevent excessive formation of free radicals. Avoid junk such as fried food and sugary drinks as they increase oxidation. Avoid spending too much time in polluted areas to protect your lungs from free radicals. Also check the sprays and chemicals you use at home. They could be adding free radicals to your body.

Don’t ignore the importance of a good night’s rest. Poor rest causes an uptick in oxidation, meaning more free radicals are produced to cause even more damage.

Additionally, many health professionals recommend optimizing glutathione levels many individuals have found significant personal benefit in doing so. In order to assist your body in maintaining optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

What are the Different Types of Glutathione Available?

glutathione

You know the dangers of oxidative stress; how free radicals can damage cells and lead to an assortment of health problems such as cancer and Alzheimer’s1 2. You may also be aware that Glutathione is a powerful natural antioxidant and one of the most effective weapons against oxidative stress3 4 5.

After reading about glutathione and oxidative stress, you may decide you’d like to supplement with glutathione, but you’ll soon discover there are many different forms of Glutathione from oral to Nano Glutathione and even IV drips.

With the large number of supplements and various opinions, studies, and conflicting information, we have assembled a list of the types of glutathione we’re aware of and the pros and cons of each type to assist you in determining which type is best for you.

Nano Sublingual Glutathione

Nano glutathione delivers over 50% of each dose into the blood stream 6 approaching the effectiveness of IV treatment with the convenience of at-home use. Instead of swallowing a capsule, this moderately priced form of Glutathione involves sublingual drops which are placed under the tongue.

The sublingual drops absorb into the blood stream through the mucous membranes in your mouth.

Pros

• Over 50% of each dose absorbed into the body 6
• Convenient since you can take it at home.

Cons

• Pricier than traditional oral Glutathione (though significantly less expensive than IV Glutathione).

Traditional Oral Glutathione

Oral Glutathione supplements are one of the most popular and oldest Glutathione supplements. They come in capsule, tablet or liquid form.

But traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness. Because they have to pass through the digestive tract, very little of the original dosage survives the acidic stomach environment. What’s left is not enough to significantly increase the amount of intercellular glutathione. Thus no benefits are conferred by these supplements.

Pros

• Inexpensive.

• Can be bought over the counter and taken at home.

Cons

• Ineffective in increasing Glutathione levels.

Oral Liposomal Glutathione

To counter the disadvantages of traditional oral Glutathione supplements, researchers have come up with a new and better form of oral Glutathione. It is called Liposomal Glutathione.

Though usually taken orally, liposomal Glutathione is able to survive the journey through the gastrointestinal system and safely reach target cells.

How does it do this?

It’s all in how the dosage is transported. To design an effective transportation mechanism, experts borrowed from how substances in the body are transported. The body uses vesicles – a special sac with a fluid in it and surrounded by a fat layer – to transport materials to and from cells. The outer membrane of the vesicle is similar to a cell membrane, making it easy for the two to fuse. The vesicle is able to easily transfer its contents into the cell.

Artificial vesicles, called liposomes, work the same way. Glutathione is carried inside these tiny sacs with a lipid layer on top for protection. They also have a membrane similar to that of a cell. Thus, Liposomal Glutathione can reach target cells while still largely intact unlike traditional oral Glutathione.

Pros

• More effective than traditional oral supplements.

• Moderately priced.

• Can be taken at home.

Cons

• More expensive than traditional oral Glutathione.

• Only moderately effective raising they body’s Glutathione levels.

• Have a very short shelf life due to the Lipid layer

Acetyl Glutathione

Acetylation is a common process in medicine. It involves the addition of an acetyl group into a chemical compound. In fact, both aspirin and heroin contain acetyl. When added to oral glutathione, acetyl makes it more stable. The supplement can therefore pass through the digestive tract without undergoing the same severe degradation that traditional oral glutathione does.

Research is still ongoing on the effectiveness of Acetyl Glutathione but early studies and anecdotal evidence shows a slight increase in Glutathione levels after taking it.

As with Liposomal Glutathione, Acetyl Glutathione was developed to provide a more effective way to orally take Glutathione supplements.

Pros

• Moderately effective.

• Easy and convenient at-home use.

Cons

• More expensive than most other oral supplements mostly because of the complex production process.

• Production process requires toxic chemicals that are not natural.

Remember in order to minimize free radical production that a diet rich in fresh fruits and vegetables has been shown to be beneficial. Exercise and rest also can be beneficial. Additionally, you may consider supplementing with glutathione and to ensure optimal levels, we recommend using Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

The Link Between Oxidative Stress and Heart Disease

heart-disease

Most serious human diseases and perhaps even the process of aging can be credited to oxidative stress1 which research has found to play a definite role in the development of such problems as heart disease and conditions relating to blood pressure2. The oxidative stress occurs largely in mitochondria from free radicals (reactive oxygen and reactive nitrogen species). Oxidative stress manifests through lipid metabolism, apoptosis, and formation of atherosclerosis, thrombosis, plaque rupture, fibrosis, myocardial injury, and failure. Recent and continuing research has generated a keen interest of both scientists and the general public in oxidative stress. This has encouraged the use of antioxidants to prevent development of oxidative stress and thus reduce the risk of heart disease which researchers believe to show much promise3.

Introduction to Oxidative Stress

Oxidative stress is better understood as the imbalance between the production of free radicals and antioxidant defenses. Oxidative stress, therefore, means the reduced ability of the body to eliminate toxins presented by free radicals (reactive oxygen species) and a leading to an inability to repair the damage caused by these free radicals. Long-term oxidative stress culminates in an enhanced formation of free radicals and peroxides. This, in turn, diminishes the effectiveness of the body’s natural antioxidant mechanism which is responsible for protecting the body against these free radicals.

The situation described is that in which the amount of glutathione in the body is diminished such that an imbalance begins to exist between the formation of free radicals and the production of antioxidant defenses. As the body’s ability to clear the toxins presented by free radicals is diminished it progressively becomes unable to repair the damage caused by these free radicals. Free radicals may damage and alter some macromolecules in cells, such as Deoxyribonucleic Acid, Ribonucleic Acid, proteins, and lipids. These alterations may develop even stronger reactive species. The effect of oxidation of DNA could be harmful as it may alter transcription and replication of many pervasive serious illnesses that are to blame for a great degree of human suffering.

As the period which the body experiences oxidative stress continues, the accumulation of these free radicals increases. In the long run, the level of free radicals in the body becomes abnormal hence degrading the self-repair system of antioxidant defense. This imbalance creates an upheaval of the normal conditions within the cells of the body.

What is Glutathione?

Glutathione is widely described as the master antioxidant of the human body. This antioxidant is naturally produced in the whole body and is found within all the cells even though its concentration in various parts of the body may differ. The antioxidant is most present in the liver but is in all other organs of the body such as the heart. It is referred to as the master antioxidant as it plays a major part the body’s defense against toxins. These are the toxins which are presented in the body by reactive oxygen species, otherwise known as free radicals.

Glutathione is the body’s natural way of preventing imbalances in the redox state in the body and is therefore tasked with the responsibility of repairing the damage caused by oxidative stress. Furthermore, glutathione attempts to decrease oxidized forms of other antioxidants like alpha-tocopherol and ascorbate in the cells of the body. Consequently, glutathione serves to reduce oxidative stress4 which according to available research plays a big role in the development of heart disease and complications relating to blood pressure5.

Oxidative Stress and Heart Disease

Free radicals, produced by the process of oxidation, are very unstable and extremely reactive. They are therefore highly toxic for tissues such as the heart. Studies performed on isolated perfused hearts have shown that even short-term attacks by oxygen radicals may cause a decline in high-energy phosphates, diminish contractile function and distort the normal structure. Free radicals may also react with unsaturated lipids and set off the process of peroxidation of lipids in the membranes.

Free radicals may also oxidize sulfhydryl groups in proteins and may also facilitate strand scission in nucleic acids. According to initial vivo studies, heart disease and complications relating to blood pressure are, to a large extent, encouraged by the formation of free radicals stimulated by auto-oxidation of catecholamine. These vivo studies have also documented the part played by free radicals in ischemia. It is these vivo studies that created a foundation for numerous further studies relating to the significance of free radicals and hence oxidative stress in the development of cardiomyopathies and heart disease.

What part does glutathione play?

When the body system is operating normally, approximately 5% of the oxygen absorbed by the cell is taken through univalent reduction (oxidation) which results in the formation of free radicals. However, the levels of free radicals in body tissues are regulated by a mechanism of natural antioxidants and free radical destroyers that are generated endogenously throughout the human body. Such antioxidants include the enzymes superoxide dismutase, glutathione peroxidase, and catalase enzyme. Superoxide dismutase is responsible for catalyzing the dismutation of superoxide anion to hydrogen peroxide, while catalase enzyme and glutathione peroxidase act as catalysts for the reduction of hydrogen peroxide to water. Besides, glutathione peroxidase eliminates other hydroperoxides that are produced through reactions of free radicals.

These natural antioxidants of the human body have been found to adapt according to physiological and pathological conditions, such as age, hypertrophy, and exercise. In pathological or disease conditions, like diabetes, high blood pressure, and heart disease among others, the formation of free radicals can supersede the self-repairing mechanism of antioxidants resulting in a situation referred to as oxidative stress.’ Various scientific and clinical research has shown that long-term oxidative stress and diminished antioxidant effectiveness have detrimental impact on the structure and functioning of the heart. Clinical studies on patients with heart disease have also given credence to the significance of free radicals and hence oxidative stress in the development of heart disease. The benefits of antioxidant therapy, such as with glutathione may also have therapeutic Benefits.

Glutathione has been shown to provide health benefits and be supportive in relation to a large number of conditions. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

Oxidative Stress and Health: Alzheimer’s Disease and Other Brain Conditions

alzheimers

Scientists and the general public have increasingly demonstrated a keen interest in oxidative stress in humans with reliable research linking oxidative stress to a myriad of serious health complications. Such complications are those conditions affecting the brain of which Alzheimer’s is an example. Various research reports have supported this argument with studies highlighting the fact that indeed most patients suffering from Alzheimer’s and other brain conditions are also experiencing long-term oxidative stress1.

Furthermore, molecular biology researchers have put forward that free radicals, which are the primary catalysts of oxidative stress are also involved in the development of Alzheimer’s and other brain conditions. Therefore in as much as the specific cause of Alzheimer’s is yet to be discovered, it is important to strive to reduce oxidative stress as part of treatment for Alzheimer’s and other brain conditions. This new scientific knowledge has led to the increased need for healthier consumption with scientists warning against modern processed foods.

Understanding Alzheimer’s Disease
The most widespread form of dementia, Alzheimer’s is a condition which greatly impairs memory and thinking. The disease is progressive and degrading and occurs in the brain. Dementia is considered a syndrome as it is as a result of a variety of symptoms. These typically include a deterioration of reasoning, communication, memory and judgment, and behavioral and mood changes. Alzheimer’s disease develops slowly, affecting different areas of the brain. As it progresses, different abilities become impaired. Consequently, a person’s behavior and abilities begin to change. The person begins to lose some of his/her abilities.

There exists in every organ of the human body, a natural self-repair system. Alzheimer’s disease and other brain conditions develop when this natural self-repair and self-healing system in the brain becomes overwhelmed. It is this system that is responsible for maintaining the healthy state of the nerve cells. This means that oxidative stress, which is the immediate consequence of such an imbalance, is a major causal factor of Alzheimer’s disease and other brain conditions.

While the symptoms of Alzheimer’s disease develop progressively and may go discovered for a long time, there are a number of factors that if present at the same time may suggest the presence of the disease. These symptoms include language problems, difficulty with abstract reasoning, mood and behavioral changes, diminished judgment, personality adjustments, problems accomplishing well-known tasks, lack of initiative, misplacing items, poor orientation of time or surroundings, and loss of memory resulting in difficulty to undertake daily activities. Each of these symptoms occurring individually or in part, however, does not mean the presence of Alzheimer’s disease. It is important to not assume without testing as these factors may be as a result of other brain conditions.

What is Oxidative Stress?
Oxidative stress describes a situation in which the glutathione levels in the body are reduced such that an imbalance is created between the accumulation of free radicals and the production of antioxidant defenses. Oxidative stress means that the body’s ability to eliminate toxins presented by free radicals is weakened making it incapable of repairing the damage caused by these free radicals. Research has proven that short-term oxidative stress can significantly impact aging through mitohormesis. However, prolonged oxidative stress encourages increased production of these free radicals. Eventually, the accumulated free radicals in the body become too much causing the self-repair system of antioxidant defense to degrade. This causes a distortion in the workings of the cells of the body.

Oxidative Stress and Brain Disease
There exists sufficient scientific evidence of the exposure of Alzheimer’s patients’ brains’ exposure to oxidative stress as the disease progresses. Oxidative stress is presented as a shift in the balance between the body’s antioxidant defense mechanism and the rate of accumulation of free radicals in the body organs such as the brain. These two elements are considered to impact the process of age-associated neuro-degradation majorly and are largely responsible for a decline in those functions of the brain which are related to logic.

The fact that oxidative stress is a part of Alzheimer’s disease is evidenced by high amounts of oxidized proteins, peroxided lipids, and final products of advanced glycation and presence of toxic species. The nuclear and mitochondrial DNA may also be modified. Alzheimer’s and other brain conditions relating to the decline in memory are associated to a weaker system of brain and plasma antioxidants defense.

The oxidative damage suffered by patients of Alzheimer’s disease and other brain conditions is linked to extremely high levels of Amyloid-β and the deposition of neurofibrillary tangles. Available scientific research has shown that bio metals such as zinc, iron and copper which are present in Amyloid-β play a key part in neuro degradation2.

There exists a definite correlation between accumulation of Amyloid-β and oxidative stress. According to scientific evidence, is known to stimulate an increase in the production of reactive oxygen species. Furthermore, Amyloid-β can corrupt mitochondria and this may also further enhance the production of these reactive oxygen species (free radicals). The effects of this increased production and hence abnormal accumulation of free radicals on the brain is manifested through increased lipid peroxidation. As a consequence, the levels of Glutathione and Vitamin E in the body are diminished. Note that glutathione is the body’s primary antioxidant which is produced naturally in all organs including the brain. This evidence was observed through a study of a mouse model whereby a mouse with Alzheimer’s disease was tested. The increased formation of reactive oxygen species has been found to increase dysfunction of mitochondria and this eventually leads to apoptosis3.

The brain generally has high energy output as a result of the activities involved in its functioning. This is associated with a higher production of reactive oxygen species (free radicals) which may subside the ability of the body’s antioxidant mechanism to eliminate the toxins presented by these free radicals. This enhanced accumulation of free radicals and hence oxidative stress is what impairs the cognitive functioning of the brain leading to Alzheimer’s disease and other brain conditions such as front temporal dementia, vascular dementia and dementia with Lewy bodies. In treating Alzheimer’s disease and other brain conditions, it is therefore important to alleviate oxidative stress. However, the genetic factors stimulating oxidative stress are beyond our control. We can seek to consume foods that are considered as more healthy and maintain a generally healthy lifestyle while maintaining optimal levels of glutathione by supplementing with high quality bio-available supplements. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

How Do I Get More Glutathione and Why Do I Need it?

veggies

Glutathione is master antioxidant that seemingly does it all. It is a naturally occurring antioxidant and it has been shown to boost the immune system1 2 3, plays a key factor in aging4 5, heart disease6 7 and dementia8, among others. It has been shown to have some impact on cancer cells as well9. Why, then, is it not featured more prominently in discussions about health and diet?

What is Glutathione?

Glutathione is a simple molecule found in plants, animals, some fungi, bacteria and archaea. It is a combination of three protein or amino acids building blocks; cysteine, glycine and glutamine. It occurs naturally in the human body, regenerating in the liver once it is depleted, hence its reputation as the master antioxidant and the mother of all supplements. Simply, glutathione could be the most important molecule in your body.

What Does it Do?

Research has shown that keeping maintaining optimal glutathione levels can have positive effects on the body. It has also been determined that more often than not, patients with diseases such as cancer and AIDS have lower than average levels of glutathione, according to Jeremy Appleton, ND, who is the chairman and head of department of nutrition at the National College of Naturopathic Medicine in Portland, and who has done extensive research on glutathione10.

Chief among its properties is its effect as an antioxidant. It plays an active role in neutralization of free radicals. These are unstable molecules that oxidize cells (oxidation stress), leaving them unstable. Hence, it acts as a natural detoxifier, ensuring our metabolism runs properly.

It makes drugs more digestible, and more soluble for excretion. It removes other chemicals that are foreign to the body.

It works as a coenzyme in several enzymatic reactions in the body, like the chemical process in which it prevents oxidation, and how it detoxifies the body.

Glutathione is essential to the immune system; it fights disease and illness, in addition to forming red and white blood cells, keeping them healthy so they can carry out their tasks efficiently.

 

Different types of glutathione available

Reduced glutathione levels have been successfully linked to several health complications and even aging. It is therefore natural to want to boost your body’s glutathione concentration. As it occurs naturally in the cell, it can be difficult to find ways to get the supplement into the body. There has been discussion over the effectiveness of taking it orally, and comparisons with intravenous methods. It can be found in various states, and taken differently. For this reason, people take precursors, the molecules needed to make glutathione instead of taking glutathione directly.

Oral glutathione: taken orally, it can be very helpful in treating glaucoma, heart disease, preventing asthma and even alcoholism, cataracts, liver disease, memory loss and Alzheimer’s disease. It is debatable how fast oral intake can raise the glutathione levels in the body.

IV glutathione: Intravenous infusion of glutathione has its benefits. It is immediate, and causes no disruption in your daily activities, although it is a bit pricier. This method has been used to counter diseases like Parkinson’s.

Liposomal glutathione: this is an artificial substance that can bind to the molecule and deliver the glutathione molecule to the body. They can be effective, but they have a short shelf life, in some cases just hours, and are often foul smelling and tasting.

Acetyl glutathione: Unlike liposomal glutathione, acetyl supplements do not use a phospholipid vessel to improve absorption. It is preferable because it does not have a foul taste or smell.

Nano glutathione: this is an oral delivery system, but unlike other supplements, the glutathione is delivered by a drip method; a drop beneath the tongue where it can be absorbed through the mucous membranes of the mouth and directly enter the blood stream.

There are some foods that naturally boost glutathione production; brussel sprouts, radish, cabbage, watercress, kale and cauliflower.

Oxidative stress

When the body has an insufficient supply of glutathione to process free radicals, it creates a condition called oxidative stress. Oxidative stress refers to an imbalance between the production of free radicals and the body’s ability to effectively counteract the harmful effects of these free radicals. It is when the free radicals in the body overwhelm its ability to neutralize them.

Free radicals are produced regularly in the body, due to the reaction brought about by cells as they produce energy. Oxygen, for all its importance in the human body, aids in the formation of these free radicals. They can also be produced by external processes and factors, such as smoking. When free radicals interact with other molecules, they can cause oxidative damage to the membranes, proteins and genes. Studies have heavily linked oxidative damage with many diseases like cancer, chronic fatigue syndrome, diabetes, anxiety and even the aging process.

The body is therefore forced to produce antioxidants to prevent this damage. Antioxidants suppress or eliminate these free radicals. Typically, it cannot produce enough antioxidants to get rid of all the free radicals. This is where diet and healthy living come in; you can help your body by increasing the level of antioxidants available to defend itself. This can be done by consuming foods rich in antioxidants, or taking supplements that boost your antioxidant levels.

Foods you can take are those rich in vitamins, particularly Vitamin C and E which assist the body in recycling its own glutathione capacity. These include vegetables and fruits like tomatoes, oranges, grapefruit, lemons and limes, spinach, asparagus, walnuts. Where you can, stick to organic foods. Avoid sugar and processed foods, as these increase the toxins in your system. Other toxins include alcohol and cigarettes.

Glutathione works well as an antioxidant due to its Sulfur content. Take foods rich in sulfur as well; garlic, cabbage, collard greens, broccoli and onions.

Oxidative stress can result from physical or emotional stress also. Fatigue, headaches and muscle pains are a few of the symptoms that can indicate oxidative stress. It will help to avoid stressful situations. Exercise also helps build up the immune system and facilitates the production of glutathione.

It is equally effective to increase the body’s antioxidant levels by supplementing the body’s natural production capacity to clear the oxidative stress. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

Autoimmune Conditions: A Closer Look at the Impact of Oxidative Stress on Immunity

autoimmune

Recent research has provided evidence that abnormal accumulation of free radicals or low glutathione increases the risk of developing autoimmune conditions. Prolonged oxidative stress has a significant role in the pathogenesis of autoimmune conditions as it enhances inflammation thereby stimulating apoptotic cell death1 2 3. In this way, oxidative stress diminishes the immunity of the body. DNA damage section of the metabolic profile is usually analyzed to determine any problems associated with free radicals then the most appropriate foods or antioxidants are given to supplement the low glutathione levels in the body.

The American Autoimmune Related Diseases Association (AARDA) says that in America alone, an estimated 50 million people suffer from autoimmune conditions. AARDA also adds that autoimmune conditions are most prevalent in families. Women make up 75% of those affected by these conditions. It is therefore likely that estrogen predisposes some women to autoimmune conditions. However, these diseases are not limited to Americans- African Americans and Hispanics are also more likely to develop an autoimmune condition. While these conditions are largely genetic, the environment also plays a role in their development.

An autoimmune condition arises when the immune system responsible for protecting the body against disease, recognizes healthy cells of the body as alien causing it to attack these healthy cells. This means that patients with autoimmune conditions generally have strange antibodies present in their circulatory system which seek to destroy their own body tissues. Various factors may trigger the immune system to attack healthy cells. These factors are such as the presence of certain bacteria or virus, chemical irritants, drugs and environmental irritants. The types of autoimmune conditions vary and they may affect one or many various types of tissue in the body. Autoimmune conditions may also distort normal growth and functioning of organs.

There exist almost 80 different kinds of autoimmune conditions, most of which present themselves almost similarly posing a great challenge in their diagnosis. Also, a person may suffer from two or more autoimmune conditions at a go. This is because the presence of one autoimmune condition furthers the risk for developing another one at the same time. Generally, people suffering from these conditions experience mild symptoms at some times and serious symptoms at other times. There is no cure for autoimmune conditions, therefore, treatment is mostly focused on alleviating the symptoms. sadly, the condition may finally lead to the death of the victim.

List of Common Autoimmune Conditions

Rheumatoid arthritis- The immune system generates antibodies that attach to the linings of joints. The cells of the immune system then attack the joints. This leads to inflammation, pain, and swelling. The joints may be damaged permanently if rheumatoid arthritis is not treated

Systemic lupus erythematosus (lupus)- People with lupus develop autoimmune antibodies which are able attach to tissues in the entire body. Lupus commonly affects the joints, lungs, blood cells, nerves, and kidneys. Treatment of lupus is administered by reducing immune system function through a daily oral dose of prednisone.

Inflammatory bowel disease – This develops when the immune system attacks the lining of the intestines. It is characterized by bouts of diarrhea, bleeding in the rectum, abdominal pain, sudden bowel movements, and fever.

Celiac sprue disease – The lining of the small intestine is corroded due to a reaction to gluten.

Pernicious anemia – The body becomes unable to absorb vitamin B-12 leading to a decrease in the concentration of red blood cells.

Vitiligo – This is characterized by loss of color pigment leading to white patches on the skin.

Scleroderma – Presents itself through changes in blood vessels, skin, muscles, and internal organs.

Psoriasis – Characterized by redness, and irritation of the skin.

Hashimoto disease – The thyroid gland becomes inflamed causing a reduction in thyroid production

Addison’s disease- insufficient adrenal hormone

Grave’s disease- overactive thyroid gland

Reactive arthritis- inflamed joints, urethra, and eyes and sores on the skin and mucus membranes

Sjogren’s syndrome – the eyes and mouth become dry. It may affect kidneys and lungs. This is due to the destruction of tear and salivary glands.

How are autoimmune conditions diagnosed?

There are various tests that may be carried out on a patient to diagnose the specific autoimmune condition they have developed. Among them are the following:

Autoantibody tests: these tests look for antibodies that the body has created against its own tissues.

Complete blood count: this test determines the quantity of white and red blood cells. The quantity of white and red blood cells is expected to deviate from the norm when the immune system is actively attacking something.

Antinuclear antibody tests: this test looks for the antibodies that attack the nuclei of body cells.

C-reactive protein (CRP): elevated CRP demonstrates inflammation in the entire body.

Erythrocyte sedimentation rate: this test determines the amount of inflammation present in the body.

Oxidative Stress and Autoimmune Conditions

Oxidative stress is known to be a condition in which there is an imbalance between the accumulation of free radicals and antioxidant defenses which suggest low glutathione. Oxidative stress reduces the ability of the body to clear toxins. Excessive oxidative stress results in the continued formation of free radicals and peroxides. These lead to low glutathione levels in the body making the body‚ immunity to weaken. This means that glutathione in the body is low such that the balance between the accumulation of toxins and the ability of the body to fight these toxins is lost. Eventually, the body becomes unable to defend itself against foreign micro-organisms.

Some macromolecules in cells may become damaged such as Deoxyribonucleic Acid, Ribonucleic Acid, proteins, and lipids. As the body continues to experience oxidative stress, the accumulation of these free radicals increases and the level of glutathione reduces. In the long term, the number of free radicals in the body becomes abnormally high hence degrading the self-repair system of the body‚ immune system. This distortion in the normal balance creates a confusion within the cellular structures of the body.

Low glutathione and general antioxidant activity along with oxidative stress are thought to contribute to inflammation, causing apoptotic cell death, and breaking down the immunological tolerance which in turn seems to be a major factor in causing autoimmune conditions4.

In order to reduce oxidative stress, you may find it beneficial to optimize glutathione levels by minimizing free radical production with healthy diet and lifestyle while supplementing with high quality bioavailable supplements. We hope you will consider supplementing with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

A Primary Cause of Diabetes You Likely Haven’t Heard Of

word-montage

Since both type 1 and type 2 diabetes have been associated with oxidative stress by researchers1 2, in this article I will discuss how to fight diabetes by reducing oxidative stress. While diabetes is widely considered as one condition, available research has shown that it is indeed a combination of various conditions which cause high levels of blood sugar levels.

The focus will be on supplementing glutathione, which is the major antioxidant that eliminates toxins and free radicals in the human body, to tackle diabetes. The rationale for this focus is derived from the heightened increase in scientific studies demonstrating the large role played by oxidative stress in the growth and development of both types of diabetes mellitus3 and the potential positive impact glutathione might have4.

The imbalance experienced between the production of antioxidant defenses and free radicals is termed as oxidative stress. It suggests, therefore, the reduced capability of vital body organs to eliminate toxins presented by free radicals (reactive oxygen species) and a consequent incapacity to repair the damage caused by these free radicals. While short term oxidative stress has been found to significantly reduce aging through mitohormesis5, severe oxidative stress reduces the effectiveness of such antioxidant defenses as glutathione whereas the production of free radicals and peroxides tends to increase. Oxidative stress thus contributes to the production of tissue damage in diabetes mellitus4 6.

As the levels of free radicals in the body become too high, the mechanisms of antioxidant defense are bound to decline. This may result in insulin resistance, damage of organelles and enzymes of the body cells and an increase in the peroxidation of lipids. In this way oxidative stress plays a role in the pathogenesis and development of diabetic complications7 8.

Glutathione and Oxidative Stress

As I mentioned earlier, glutathione is the primary antioxidant in the human body. This antioxidant is synthesized endogenously in the entire body and is present in all the cells with varied concentrations. The highest concentrations, however, are found in the liver. Glutathione is considered the primary antioxidant because of the roles it plays in detoxifying electrophilic xenobiotics, regulation of immune responses, deoxyribonucleotide synthesis and antioxidant defense.

As free radicals are generated in excess of the body’s natural ability to clear and neutralize them, the body suffers from oxidative stress. Free radicals are unstable oxygen molecules which can damage DNA and impair the functioning of organs such as the liver. Ideally, atoms share electrons with other atoms to form molecules consisting of stable atoms. Stable atoms are those which have equal pairs of electrons and protons.

Free radicals are formed when a molecule splits leaving an atom with an electron that is unpaired. This unstable atom then attacks other molecules in attempt to take an electron causing a chain reaction of formation of free radicals. This chain reaction disrupts the balance within living cells. Glutathione is therefore responsible for maintaining a balance in the redox state in the body which includes repairing the damage resulting from oxidative stress. Within the cells, glutathione serves to decrease oxidized forms of other antioxidants like alpha-tocopherol and ascorbate. Consequently, glutathione helps to reduce oxidative stress which is a key contributing factor in the development of complications relating to diabetes hence helping in the fight against both types of diabetes.

The Need to Supplement Glutathione

The human body’s capacity to naturally produce glutathione is reduced by 1% every year over the age of 209. Also, many people have a reduced capacity to naturally produce this antioxidant as a result of genetic mutation, modern diets, and a toxin-ridden environment10. Glutathione is also attacked directly by free radicals and other oxidative agents. These combined factors lead to an increase in the presence of toxins and free radicals in our bodies. This may result in the body being unable to produce sufficient glutathione for its protection which can lead to oxidative stress.

Furthermore glutathione in the human body is subjected to strict homeostatic control inside and outside the cells. This is to ensure the maintenance of a complex balance between the synthesis, recycling and utilization of reduced glutathione (GSH) from oxidized glutathione. The recycling of reduced glutathione is catalyzed by glutathione disulfide reductase. Reduced glutathione is conserved by the reducing power of ascorbate. This cycle tries to ensure reduced glutathione is produced as it is used up. Still, the synthesis of glutathione can be slower than its depletion. This has necessitated the supplementation of the natural production capacity of the body.

Glutathione Supplements

Exogenous forms of the primary antioxidant of the body exist. The various forms range in price, bioavailability and convenience. Some of these oral glutathione supplements have been shown to be borderline ineffective11 12. Nanoceutical Solutions has recently developed a nano sublingual glutathione supplement that delivers approximately 60% of each 200mg dose of I-glutathione after about 90 seconds after contact with the mucous membranes13. The supplement can be taken at home and does not require IV injections which are as expensive as they are painful. Nano Glutathione is a simple daily drop administered sublingually under the tongue.

 

Glutathione has been shown to provide health benefits and be supportive in relation to a large number of conditions. In order to maintain optimal glutathione levels, consider supplementing with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

References

  1. Wu G1, et al Glutathione metabolism and its implication on health. J Nutr. (2004)
  2. Https: //draxe.com/glutathione/#
  3. Proceeding of the National Academy of Sciences (1970) Marian Orlowski and Alton Meister 67: 1248-1255