De-mystifying Glutathione – The Most Powerful Antioxidant For Your Body



Glutathione is a Master Antioxidant taking the health industry by storm. It was previously exclusively available through expensive injections, but has now surfaced the public sphere through a technique called Nano-Sizing. We asked the Co-Founder of Nano Glutathione 10 frequently asked questions about this powerful antioxidant.


1. What exactly is Nano Glutathione?

Nano Glutathione is L-Glutathione, sometimes referred to as reduced Glutathione, which basically means that it has an extra electron and is ready to neutralize free radicals.

What makes our product so unique is that it has been Nano-Sized using our proprietary patent pending process. By reducing the actual particle size of the Glutathione into the Nano Size (Sub-Micron) range, our Nano Glutathione can be applied directly onto the mucosal membrane of the mouth and is absorbed directly into the bloodstream, bypassing the stomach and gastrointestinal (GI) tract, where hydrochloric acid destroys Glutathione before it can be absorbed.

2. If Glutathione is the 2nd most important molecule in the human body, why don’t more people know about it?

Glutathione is made in every cell in your body and it has some very important functions, but Glutathione is ineffective when taken in pill form because it will get broken down and destroyed during digestion before it can be absorbed.

Because the ineffectiveness of oral supplementation with pills is well documented, Glutathione is not commonly found on the vitamin shelf in health food stores or discussed by many personal Physicians. But that is starting to change and Glutathione is just starting to become more mainstream.

We are seeing the change now, in fact when we were developing our technology and would tell someone we are “Nano-Sizing” Glutathione to make it bioavailable, they would always ask “What is Glutathione?”  Today when we talk about Glutathione around half the people we engage know about Glutathione or have at least heard about Glutathione.  We believe as more medical and scientific experts begin to make the correlation between low levels of the Glutathione and the likelihood of chronic disease, that Glutathione will continue to get a lot of attention and become the cornerstone of any supplementation regime.

3. What is the connection between stress and glutathione levels in the body?

In healthy people there is an inverse relationship between Oxidative stress and Glutathione; the higher the levels of Glutathione = lower levels of Oxidative Stress, but unfortunately most people have low levels of Glutathione and very high levels of oxidative stress.

Oxidative stress leads to negative conditions in the body. Everything from neurodegenerative diseases such as Parkinson’s disease & Alzheimer’s disease, gene mutations and cancers, chronic fatigue syndrome, joint pain, heart and blood vessel disorders, atherosclerosis, heart failure, heart attack and inflammatory diseases.

4. Why does Nano Glutathione work so well for hangovers?

When the liver breaks down alcohol, it turns into something 10 times more toxic called acetaldehyde. Acetaldehyde cannot be neutralized for removal from the body without glutathione. The older you get, the less glutathione your body can make. This results in a slower removal of alcoholic byproducts, and longer lasting, more intense hangovers.


5. How long did it take for the formula to be created?

It took 3 years for us to formulate, develop, and test Nano Glutathione.  

We are able to physically manipulate the Glutathione and reduce its size more than 20,000 times its original size without destroying the covalent bonds of the Glutathione. We have custom built cGMP processing equipment that enables us to safely Nano Size the Glutathione. The production process takes several days to complete and cannot be interrupted once started.

6. Are there any side effects?

Yes-  it whitens skin and can reduce the effectiveness of chemotherapy.  (The skin whitening is actually a primary reason a lot of people in Asia, and South America administer Glutathione injections.)  But the most common side effect or reaction is due to your body rapidly detoxing. Some customers that are in a severe state of oxidative stress have reported symptoms of early detoxification results.

This wide range of bodily reactions is collectively known as the Herxheimer Reaction (sometimes called a Herx Reaction, or simply Herx). The reaction is typically short-lived, from a few days to at most a few weeks. This reaction includes any circumstance where the volume of toxic material exceeds the capacity of the body to eliminate it. As the body detoxifies, it is not uncommon to experience flu-like symptoms including a headache, joint and muscle pain, body aches, sore throat, general malaise, sweating, chills, nausea or other symptoms.

If anyone should experience the symptoms of a Herxheimer reaction, please don’t be alarmed. These reactions are signs that the body is hard at work cleansing itself.

To help mitigate these symptoms you can reduce the amount of glutathione you are taking and or skip a day in-between taking it. In addition, it is a good idea to drink plenty of water, eat well in terms of fresh fruit and vegetables and exercise as much as possible. All of these steps will assist the body in mitigating the effects of detoxification.

7. When’s the best time to take Nano?

You can take Glutathione anytime that is convenient for you.  Just be sure to not eat or drink anything for 3 minutes after administration.  This will ensure you get a full 200mg/ml dosage and allow it time to permeate the mucosal membrane.  As with any supplement it is best to find a time to take the Nano Glutathione that works best for you and stick to that time daily.  This will ensure you do not forget to take the Nano Glutathione daily.


8. Have you been taking it yourself?

Yes, I take the product daily. I started about two years ago. I have more energy, improved mental clarity, no joint pain, and have not been sick in two years.

9. Are there a few examples you can give as to how it’s changed other people’s lives?

We have so many positive testimonials and comments that we would love to share. My personal favorite involves a lady who suffered from migraines for decades and was diagnosed as borderline MS after an MRI showed multiple lesions on her brain. After the first dose, she woke up without a headache for the first time in ages. After taking our product for six months, only the largest of lesions remained, and those were much reduced. She avoided the MS diagnosis, and her neurologist said it was nothing short of a miracle.

10. What was the inspiration for the product?

We wanted to make a product that would have a significant positive impact on people lives. We chose Glutathione as our first product to develop because Glutathione was known to have zero oral bioavailability.  It was a great proof of concept product to show that our proprietary Nano-Sizing process could make a well known non-bioavailable supplement – bioavailable.  

Our mission is to produce vitamin products that make a tangible improvement to people’s health, and their quality of life. The older you get, the more you realize how precious your health is. So whether people are looking for preservation, prevention, or recovery of their health, we want to help make their goals a reality.

 Feel Better Today, Try Nano-Glutathione.

What is the “Mother of All Antioxidants”



We are all motivated by an overwhelming desire to be healthy. We want all of our loved ones to be healthy – kids, partners, friends, and even pets.

Yet “Healthy” holds a different definition for each and every one of us. Is it having more energy and better quality sleep? Reaching a weight goal? Being less stressed? Avoiding the common cold?

But there is one common denominator that ties everything together… Our Cells.

Unless we take care of our cells, any form of  “staying healthy” will fall short.

ANTIOXIDANTS are what protect our cells and DNA from toxic free radicals and oxidative stress that may be the underlying issue to many health risks.   

Unfortunately, blueberries and avocados don’t often cut it.

Our bodies need “The Mother of All Antioxidants” aka Glutathione

Glutathione is made in every cell in your body. It protects against oxidative stress, which leads to negative conditions in the body- everything from neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease, gene mutations and cancers, chronic fatigue syndrome, joint pain, heart and blood vessel disorders, atherosclerosis, heart failure, heart attack and inflammatory diseases.

If You Haven’t Heard of Glutathione, You Need To Read This:

Health problems start at a cellular level. Glutathione is one of the most important Antioxidants for your body, protecting and rejuvenating your cells. Along with defending your body against oxidative stress, Scientists have pointed to the many health benefits of Glutathione.

Unfortunately, Glutathione levels decrease as you age- especially with the increasing amount of outside stressors taxing your body. Therefore, it is important to replenish your body’s supply.

How Glutathione Can Change Your Everyday Routine…  

Can’t focus at work? Not getting enough sleep? Sick too often?

These things add up. Sometimes we need a little help from our friend Glutathione

Glutathione has been clinically proven to:

B – Boost your immune system

I – Increase Mental Clarity

G – Gain Energy  

For these reasons and more, it has been deemed “The Miracle Molecule.” Glutathione  supports a strong immune system, sharp focus, and consistent level of energy that makes a BIG difference throughout the day.

So you may be asking… “HOW DO I GET IT??”

Nano Glutathione has made this “Mother of All Antioxidants” available to the general public through Sublingual Drops.

This is HUGE because up to this point, Glutathione was exclusively available to those who could afford the insanely expensive injections (celebrities and millionaires). It has also been available in pill form, but our bodies can’t even absorb them. (More about this below)

Now anyone can benefit from the effects of Glutathione through Nano.

Remember, BIG changes start with little drops.

Other Things You Should Know About Glutathione…

Nano-Glutathione Can Help Cure A Hangover

When the liver breaks down alcohol, it turns into something 10 times more toxic called acetaldehyde. Acetaldehyde cannot be neutralized for removal from the body without Glutathione. The older you get, the less glutathione your body can make. This results in slower removal of alcoholic byproducts, and longer lasting, more intense hangovers.

Why Doesn’t Glutathione Have A Shelf Life?

Glutathione is ineffective when taken orally because it will get broken down and destroyed during digestion before it can be absorbed. Because the ineffectiveness of oral supplementation is well documented, Glutathione is not commonly found on the vitamin shelf in health food stores or discussed by many personal Physicians. But, this is starting to change and Glutathione is just starting to become mainstream.  

My Main Squeeze – Quit the Hassle of Taking Pills

Hate swallowing pills, dropping them on the floor, or dealing with an upset stomach afterward?

What makes Nano Glutathione so unique is that it has been Nano-Sized, meaning it can be applied under the tongue and is absorbed directly into the bloodstream, bypassing the stomach and gastrointestinal (GI) tract, where hydrochloric acid destroys Glutathione before it can be absorbed.

Nano Glutathione sublingual drops is the most effective way to take Glutathione, but we can all admit that using a dropper is actually kind of… fun?

Test it out for yourself, it’s oddly satisfying.

Can The “Mother of All Antioxidants” Be Trusted?

Just turn on the TV to see the results. Celebrities have been paying big money for Glutathione injections over the years for its anti-aging properties.

In addition, an extensive amount of research has been conducted and multiple case studies have pointed to the radical health benefits. See this woman’s testimony for how it helped her brain lesions.

Lastly, Jonathan, the co-founder of Nano Glutathione, gave us some insight into the power of Nano Glutathione:  

“Our mission is to produce vitamin products that make a tangible improvement to people’s health, and their quality of life. The older you get, the more you realize how precious your health is. So whether people are looking for preservation, prevention, or recovery of their health, we want to help make their goals a reality.

Here’s to one squeeze a day, because BIG changes start with little drops.  

Order Nano Glutathione Here


Why Everyone Should Know About “The Mother of All Antioxidants”


Why aren’t people educated on the 2nd most important molecule in your body other than H2O?

It seems unthinkable that people haven’t heard of this master antioxidant before, so we decided we need to give you the facts.

Buckle in! If you struggle with stress, low energy, mental fog, or a poor immune system, this is going to be some of the most important information you’ve ever received.


Glutathione is the Master Antioxidant

It is the most important antioxidant your body needs to fight off free radicals, reduce oxidative stress and protect your cells. Scientists and Health experts cannot emphasize enough the importance of Glutathione for anti-aging, immunity, and mental clarity.

But here’s the problem…


Glutathione Levels Decrease as You Age

Why am I dragging during the day? Why am I drinking 5 cups of coffee? Why am I sick every other week?

If you’re asking these questions, it’s important you understand that problems start at a molecular level.

Yes, stressors in your job, relationship, and finances may all be contributing to poor health. And it is important to exercise care. But what’s just as important (or maybe even more so) is what’s happening inside your cells. If your cells aren’t happy, nothing else in your body is.

Our bodies are tired of defending against constant stressors. We jam our medicine cabinets full of pain relievers, vitamins, and supplements in the hope they make us “healthier.” Yet in turn, this has become a meaningless buzzword.

The Real Issue:

Our Glutathione levels are dramatically decreasing because our bodies are taxed with toxic stressors, unhealthy foods, and bad habits.

These factors accelerate aging and deplete our Glutathione, which is detrimental to our energy levels, ability to focus and immune system.

So cozy up and get familiar with Glutathione because it is the #1 Antioxidant your body needs to:

  • Combat Stress
  • Gain Energy
  • Increase Mental Clarity
  • Boost Your Immune System
    … oh, and cure your hangovers (they don’t call it the ‘Miracle Molecule’ for nothing).

Glutathione is vital to your body’s detoxification process, and in-turn powers your liver cells to filter alcohol out of your system.


There Are Reasons You Haven’t Heard of This “Miracle Molecule”

Glutathione isn’t new. Scientists and Doctors have been selling this anti-aging secret to celebrities and millionaires for decades.

That’s right, people who had the money to afford it have been splurging on Glutathione and reaping the health benefits.

Previously, Glutathione was only available in the form of injections – painful and expensive  (up to $4,000 per month!). Then scientists figured out how to make it an ingestible capsule, called Liposomal Glutathione – but this proves to be a difficult and inefficient way of taking Glutathione because your stomach acids prevent absorption.

This leads us to our last point…


You Can Boost Your Glutathione Levels Starting Today

Some nutritionists will recommend eating certain vegetables such as spinach, broccoli, kale or cauliflower, but a growing number of health experts are saying the only way to substantially increase Glutathione levels is through sublingual supplementation.

Nano Glutathione is disrupting the market by providing a solution to the outrageously expensive injections and subpar capsules. These drops are easy and effective.

One of the boldest steps we can all take is to fuel our bodies with powerful nutrients. We’ve been so amazed at what scientists are saying about glutathione and think it’s important to pass on the word.

Click here to learn more about Nano Glutathione.

Symptoms of Detoxification (The Herxheimer Reaction)


Glutathione is the most powerful detoxification agent produced within the human body. When we supplement with glutathione, we can increase the capacity of our body to eliminate toxins, and this can also influence our body to detoxify itself rapidly.

Rapid detoxification can result in some discomfort, which is experienced through a wide range of bodily reactions. This experience of reactions is collectively known as the Herxheimer Reaction (sometimes called a Herx Reaction, or simply Herx). The reaction is typically short lived, from a few days to at most a few weeks. This reaction includes any circumstance where the volume of toxic material exceeds the capacity of the body to eliminate it.

The primary channel of elimination within our bodies is the lymph system, which connects to every cell, working around to clock to dispose of toxins, waste, dangerous bacteria, viruses, or other microorganisms. It’s components include a vast network of vessels, nodes, and organs that circulate lymphatic fluid. This fluid (often referred to as just “lymph”), has a lot in common with blood. But unlike blood, there is no heart to pump and move the lymph. Instead, the body pressurizes the lymph vessels and pumps the fluid through the movement of muscles and joints.

The lymph system is often referred to as the garbage collector of the human body. When garbage fails to be collected or disposed of properly in society, it creates havoc and interrupts the normal flow of life. The same is true for the body. When our bodies cannot eliminate waste fast enough, the lymph system can get backed up, clogging the vessels and disrupting vital bodily functions. This is what generates the Herxheimer Reaction, and it can be experienced through a broad range of symptoms.

If anyone should experience the symptoms of a Herxheimer reaction, please don’t be alarmed. These reactions are signs that the body is hard at work cleansing itself. Some of the uncomfortable symptoms one may experience are outlined below, but they vary from person to person.

  • Headaches
  • Joint Stiffness
  • Muscle Pain
  • Cramps
  • Fatigue
  • Insomnia
  • Hyperactivity
  • Anxiety
  • Irritability
  • Fever
  • Chills or Hot Flashes
  • Bad Breath
  • Excess Bowel Movements
  • Diarrhea
  • Constipation
  • Rashes
  • Acne
  • Abnormal Heart Rate
  • Change in Blood Pressure
  • Hyperventilation
  • Swollen Glands
  • Flu-like Symptoms

The backup of lymph forces the body to take alternative, less ideal actions to remedy the excess waste. This can be helped greatly by taking proactive measures to improve the flow of lymph and reduce the severity of the reaction.

First, if the lymphatic system is overloaded, one can always reduce the amount of Nano Glutathione you are taking. This will give the body a chance to catch up. When the symptoms subside, it is possible to experiment with increasing the dosage.

Second, the lymphatic system relies upon fluidity to move. The liquid for this fluidity is pulled from the water that we drink and the food that we eat, so it is essential to drink lots of water and eat as much as possible in the way of fresh fruits and vegetables.

Third, the lymphatic system relies upon the motion and activity of the body to circulate and eliminate the waste. Exercise will force the lymph to move, and even moderate movement will help. The ideal exercise to move the lymph is a rebounder, which is similar to a trampoline. This up and down motion opens and closes the lymph nodes, and forces the fluid to move through the vessels. That may not be an option for everybody, so simply walking, running, bike-riding, swimming, or any other form of exercise will help the body out. If none of these options are available, then a massage can also be of great benefit. The majority of the lymphatic vessels are close to the surface of the skin, and the fluid can be moved through manual manipulation. This can even be done to oneself if it is not possible to procure a massage.

Fourth, rest is required. The body is working hard to detoxify itself, and this consumes a lot of energy. Paying close attention to the signals the body sends when it needs to rest is essential, along with trying to avoid stress, and performing any available relaxation techniques.

Herxheimer Reactions are typically short-lived. They can last for up to a few weeks, but they are most often resolved within the span of a few days. If you have any serious concerns about any specific reaction you may have after starting to take this product or any other product, you should consult your primary care physician. The information provided is for educational purposes and not intended to be or replace medical advice from your licensed healthcare professional.

Diet and Exercise are not the Only Factors Related to Weight Gain and Obesity


What Hollywood Stars have known for years has now been validated with new evidence from scientific research conducted at Baylor College of Medicine, that suggests as we getlolder, we getlfatter 1. Additionally other research has shown that stubbornlbellylfatlandlobesity may actually be caused by the oxidative stress that is generated as a result of toxins and free radicals produced by thelbody following chronic consumption oflsugars andlcarbohydrates 2.Research also suggests that uncontrolled buildup of these toxins and free radicals (called oxidative stress), leads to a condition where thelbody stores morelfat and uses lesslcalories makinglweightlloss much more difficult andlweightlgain much easier 2. Maybe some of you have experienced the frustration of cuttinglcalories and starting tolexercise, only to see the scale stare back at you each day not moving or even moving the wrong direction.

For many of us, including myself, the battleloflthelbulge has been a lifetime battle that I have been losing over the years. What I’ve recently learned is that the complex biochemical process that governs how muchlfat we store, how much we burn, and howlhungry we are malfunctions under heavy toxic load, making it easier to storelfat 2. When we try to startlexercising and change ourldiets, all we find is frustration because ourlbody’s natural processes aren’t functioning correctly anymore due to this high level of toxicity.

In addition to the toxic load, free radicals, and oxidative stress that is created over time by eating the wronglfoods mentioned above, artificiallsweeteners,ldietlproducts, andldiet pills all add additional toxins to the body, just pushing thelbody further out of balance and making it easier to store morelfat.

Luckily for for me and now for you, I accidentally stumbled onto a solution that helps break this cycle. This is my story of how I discovered thatlmetabolic rate andlfat storage are affected by the levels of oxidative stress 2 and free radicals and toxins left unchecked develop into this state of oxidative stress.

My Journey with Nano Glutathione

profileI initially started taking Nano Glutathione to improve my overall health and well being. Glutathione has been featured in over 89,000 studies and low glutathione has been linked to variousldiseaseslincludinglobesity,ldiabetes, heartldisease, lcancer, Alzheimer’s,lParkinson’s,lprematurelaging,lAutism, eczemalandlpsoriasis, rheumatoidlarthritis, autoimmuneldiseases, osteoporosis,lseizures and more 3-11.

I did not start taking Nano Glutathione with any specific expectation on what it might do for me, but once I realized there were some changes in mylbody, I decided to research the relationship of glutathione and this complex set of hormones that controllmetabolism,lfat storage, andlhunger in thelbody which I’ll come back to a little later, but first my incredible story.

Almost immediately after I startd taking Nano Glutathione, I noticed an increase in energy. My hair dresser even commented on the fact that I had noticeably less greylhair 12 on the sides of my head where it had been slowly taking over. My skin on my face was clearer and less puffy 13. My blood pressure went down about 10 points 14. In general I felt great.

plateauI have a regular gym schedule but had been stuck for some time atlalweight plateau. I wouldn’t say I amlfat, but I’m notlskinny either. I’ve typically always carried “alfewlextralpounds” even though I am healthy enough. Additional effort tolexercise harder or to maintain more discipline with myldiet didn’t really ever seem to produce much in the way oflfat loss and so I had just kind of resigned myself to the fact that having a few extralpounds is just what happens as youlage.

I continued with my normal gymlschedule and my normalldiet which isn’t too heavily laden with unhealthylfoods, but I wouldn’t classify as overly healthy either. During the first few weeks I wasn’t really paying that close of attention to mylbody and wasn’t really expecting any changes. One morning my partner looked at me, and said, “Baby, I think you’re finally making progress with thatldietlandlexercise routine.” This prompted me to begin my research into the role glutathione plays in thelbody.

I spent hours researching the complexities of how oxidative stress affects the metabolism and can causelweightlgain 2. Once I’d summarized my research, I shared it with Nanoceutical Solutions, the company that makes Nano Glutathione and was honored with a request by the company to share this blog article with their facebook followers and community as there are millions of people in the US struggling with the same issues of just not being able to make any progress in spite of significant changes toldietlandlexercise.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Leptin,lInsulin,lGlutathione, andlWeightlLoss

The mechanisms of how toxins and oxidative stress contribute tolweightlgain and prohibitlweightlloss are complex, and have only recently been brought to light through scientific research. The key players arelinsulin,lleptin, oxidative stress, and inflammation.

Insulinlis a hormone produced in the pancreas, and is responsible for regulating bloodlsugar and various hormones in thelbody.lInsulinlis the key that unlocks the cell, allowing the cell to absorb glucose, which comes fromlcarbohydrates in yourlfood such aslsugar andlstarches (bread,lpasta,lpotatolchips, etc). Thelglucose is then either used as energy, or converted intolfat. The morelcarbohydrates in yourlbody, the morelinsulin yourlbody will create.

leptinLeptinlis a hormone secreted bylfat cells.lLeptinlprovides feedback to your brain regarding the amount oflfat stored in yourlbody, and regulates your brain’s sense of beinglhungry. The morelfat in yourlbody, the morelleptin yourlbody will create. Also, elevatedlinsulin levels will cause the secretion of morelleptin.

Leptinlcauses oxidative stress in thelbody, which results in inflammation. This is a normal part of thelmetabolic process. As mentioned earlier, thelbody’s ability to address oxidative stress is dependent upon glutathione reserves, which are limited and decrease with age and with consumption and exposure to toxins.

Where things get out of control is during the process oflovereating, and especiallylovereating simplelcarbohydrates andlsugars.lOverconsumptionloflfood, even temporarily, causes an inflammatory state of oxidative stress in your cells that leads tolinsulin resistance, becauselinsulin cannot easily pass through a cell when it is inflamed. Yourlbody’s response to this is to create morelinsulin, which forces even morelleptin to be secreted.

The brain becomes desensitized tolleptin easily, driving ongoingloverconsumptionloflfood because the “stopleating” signal is not being received properly.lOvereatingloflcarbohydrates is especially dangerous to this process due to the relationship oflinsulin andlleptin. Carbslincreaselinsulin,linsulinlincreaseslleptinllovereating increaseslleptin, and all of this increases oxidative stress and inflammation which depletes your glutathione. To make matters worse, yourlbody’s glutathione production is reduced under high levels of oxidative stress, meaning there is less glutathione to clean out the increasing amounts of toxins and free radicals 14. You can see how this creates a nasty feedback loop that can be impossible to escape from when thelbody cannot handle the toxins and free radicals. It leads to rapidlweightlgain,lmetabolicldisorder,ldiabetes,land potentially numerous otherldiseases 15.


So how do you get out of this trap? The first step is to help yourlbody reduce the inflammation and oxidative stress, while at the same time adjusting yourldiet. In my case, I had already made adjustments to my diet and had also added moderatelexercise to my daily routine, but mylbody wasn’t responding to these changes because I had not addressed the oxidative stress and inflammation adequately. By adding Nano Glutathione to what I was already doing, I was addressing the oxidative stress in mylbody and working to clear the free radicals and toxins.

What It All Means

Even with a background in science, this is very confusing stuff and the relationships of all these hormones in thelbody are just now starting to be understood by the experts. But one thing is becoming increasingly clear. The relationship of thelmetabolism andlfatlstorage is not just a simple relationship of how manylcalories youleat and how manylcalories you should be burning. Oxidative stress and low glutathione can slow the amount oflcalories you burn and increase the amount oflcalories you store, makinglweightlgain possible even when cuttinglcalories and increasinglexercise.

Reducing inflammation and oxidative stress by increasing glutathione levels has been shown in recent research to assist thelbody in rebalancing its natural processes including thelmetaboliclrate to optimal levels 16. This means for someone like me who was making the effort toleat lesslcarbohydrates, fewerlcalories andlexercise more, that by reducing oxidative stress andlinflammation while also increasing glutathione levels, it’s possible to see improvements where they weren’t possible before.

What is Glutathione?

Glutathione is widely accepted by the medical community as a primary antioxidant and intracellular detoxification agent in thelbody. Mark Hyman, Director of Functional Medicine at the prestigious Cleveland Clinic and Medical Editor for the Huffington Post stated this about Glutathione:

“It’s the most important molecule you need to stay healthy and preventldisease — yet you’ve probably never heard of it. It’s the secret to preventlaging,lcancer,lheartldisease,ldementia and more, and necessary to treat everything fromlautism tolAlzheimer’sldisease. There are more than 89,000 medical articles about it — but your doctor doesn’t know how to address the epidemic deficiency of this critical life-giving molecule. What is it? I’m talking about the mother of all antioxidants, the master detoxifier and maestro of the immune system: GLUTATHIONE.”

The main reason you probably haven’t heard of glutathione, is that until recently direct oral supplementation was ineffective because glutathione is destroyed in the digestive tract before being absorbed 16. Consequently, increasing glutathione levels has been largely limited to expensive and painful IV treatments (over $1000 a treatment), or supplementing with oral glutathione precursors such as whey protein, NAC, cysteine, and glycine among others.


As I mentioned earlier, low glutathione levels have been linked to a large number ofldiseases includinglobesity,ldiabetes,lheartldisease, cancer,lAlzheimer’s,lParkinson’s,lprematurelaging,lAutism,leczemalandlpsoriasis,lrheumatoidlarthritis,lautoimmuneldiseases,losteoporosis,lseizureslandlmore. In addition to low glutathione being linked to variousldiseases, maintaining optimal glutathione levels has also been linked tollongevity. In a study over 5 years on healthy women between the ages of 60 and 103 found that all subjects had very high levels of glutathione in their bloodstream 17.

Why is Nano Glutathione Different?

I was one of the early recipients of this new breakthrough supplement from Nanoceutical Solutions called Nano Glutathione. This supplement uses revolutionary technology to dramatically reduce the particle size of the glutathione to 1/20,000 of normal glutathione causing an amazing absorption rate of nearly 60% within seconds of oral ingestion 18. This allows these molecules to pass straight through the lining of the mouth and directly into the bloodstream. By comparison, a study by Bastyr University Research Institute and the University of Washington on the effect of taking traditional oral glutathione found no significant changes in the biomarkers of oxidative stress, including glutathione levels 19.


Supplementing With Nano Glutathione

Nano Glutathione was made available to select participants including myself over the last few months ahead of Nanoceutical Solutions selling the product publicly. The accounts below are a few of those participant’s reports following taking Nano Glutathione.


Brad, a 43 year old from Houston, TX had been diagnosed with elevated liver enzymes and borderline high blood pressure. He received Nano Glutathione from Nanoceutical Solutions and within a month his liver enzymes had returned to normal and his bloodlpressure had returned to the normal range. He reported back his results to the company and purchased additional bottles in order to maintain optimal wellness and keep hislbody free of oxidation. During the next 4 weeks after receiving his new supply of Nano Glutathione he experienced significant changes in hislbody without changing hisldiet orlexercise routine.

EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Barbara, age 73 and Cliff, age 75 from Hillsboro, have been taking Nano Glutathione for the last month before this article was written. Barbara started taking Nano Glutathione with the hope it would relieve some of the memory issues she was having as she’d read thatldementia andlAlzheimer’s had been linked to oxidative stress. After just a few weeks, she reported back that her memory was much better, that she was achieving new high scores almost daily on her favorite game Word With Friends and that she was having a much easier time remembering the things she needed to do without having to retrace her steps all the time. Additionally she reported that her jointlpain had subsided significantly and most recently she reported that she had she and Cliff had experienced positivelbody changes without adding or changing anything in their routine orldiet but adding Nano Glutathione.


EDITOR’S NOTE: The results presented are remarkable and since there is strong evidence showing the connection tolleptin andlinsulin resistance, inflammation and oxidative stress, and low glutathione levels, Nano Glutathione may benefit a large number of people including those struggling with the conditions above, but people’s individual results will vary and the results above may not be typical.

Try it For Yourself

Brad, Barbara, Cliff and I all received our Nano Glutathione direct from the manufacturer Nanoceutical Solutions. Nanoceutical Solutions manufactures their Glutathione in San Antonio, Texas in an FDA registered facility and they manufacture all their supplements with pharmaceutical grade ingredients. The company is a also a member of the BBB and they stand behind their products by offering a 90ldaylmoneylbacklguarantee on first time purchases, and al30ldaylguarantee on any repeat purchases. You can try it for yourself by clicking this link or the link below. And please come back and let us know how it worked. We’d love to share your experience. And as with all supplements, everyone is different and results may vary.

Representations regarding the efficacy and safety of Nano Glutathione have not been evaluated by thelFood and Drug Administration. The FDA only evaluateslfoods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure anyldisease. It is recommended that users follow a strictldiet andlexercise regimen to achievelweightlloss results. These products are not intended to diagnose, prevent, treat, or cure anyldisease. Click below to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of glutathione based on the expertise of relevant professionals.

  1. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione
    Dan Nguyen-Susan Samson-Vasumathi Reddy-Erica Gonzalez-Rajagopal Sekhar –
  2. Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals
    Shaimaa Ahmed-Firas Maher-Nazar Naji –
  3. Oxidative Stress and Obesity: The Chicken or the Egg?
    Annayya Aroor-Vincent DeMarco –
  4. Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients
    Dan Nguyen-Jean Hsu-Farook Jahoor-Rajagopal Sekhar –
  5. lutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori-Suzanne Krance-Sylvia Notenboom-Shujie Shi-Kim Tieu-Christine Hammond –
  6. The emerging role of glutathione in Alzheimer’s disease.
    S Saharan-P Mandal –
  7. Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine
    Rajagopal Sekhar-Siripoom McKay-Sanjeet Patel-Anuradha Guthikonda-Vasumathi Reddy-Ashok Balasubramanyam-Farook Jahoor –
  8. Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study.
    O Sendur-Y Turan-E Tastaban-C Yenisey-M Serter –
  9. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction.
    W Dröge-E Holm –
  10. Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes, and gastric mucosa of man.
    C Loguercio-D Taranto-L Vitale-F Beneduce-C Del –
  11. The glutathione defense system in the pathogenesis of rheumatoid arthritis.
    M Hassan-R Hadi-Z Al-Rawi-V Padron-S Stohs –
  12. Oxidative Stress in Ageing of Hair
    Ralph Trüeb –
  13. Skin anti-aging strategies
    Ruta Ganceviciene-Aikaterini Liakou-Athanasios Theodoridis-Evgenia Makrantonaki-Christos Zouboulis –
  14. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants
    Azar Baradaran-Hamid Nasri-Mahmoud Rafieian-Kopaei –
  15. Glutathione: a key player in autoimmunity.
    C Perricone-C De-R Perricone –
  16. Glutathione Depletion/Methylation Blockades in Chronic Fatigue Syndrome
    2012 4 –
  17. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.
    C Lang-B Mills-H Lang-M Liu-W Usui-J Richie-W Mastropaolo-S Murrell –
  18. Nano Glutathione Diffusion Study Results
  19. Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers
    Jason Allen-Ryan Bradley –
  20. Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging
    Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 Tweet share- Dipali Pathak713-798-4710Houston, TX – Apr 2, 2013 –



The information presented on this website is not intended as specific medicalladvice and is not a substitute for professional treatment or diagnosis. These statements have not been evaluated by thelFood and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent anyldisease.

All trademarks on this site whether registered or not are the property of their owners. The authors of this site are not sponsored or affiliated with any of the 3rd party trademark or owners and make no representation about them, their owners, products or services.

Disclosure Regarding Endorsements and Testimonials – Some of the people quoted throughout the website, whether consumers, celebrities, experts or otherwise, have benefited in some way in return for their testimonial or endorsement of the product. Many of the endorsements are simply unsolicited emails, calls or blogs from contented customers but other endorsers have received free products.

Why Do I Need Glutathione if I’m Healthy?


Through evolution, the human body has developed a variety of protective measures against the many dangers it faces from things like pathogens and toxins. Glutathione is one of the most impressive guards the body possesses. This potent antioxidant neutralizes dangerous toxins and free radicals in the body1.

Low levels of glutathione in the body have been linked to a decline in health. Conditions such as chronic fatigue2, reduced memory performance3, accelerated aging4 and many others have been linked to low glutathione.

People with certain ailments tend to be at a greater risk of glutathione deficiency and hence have the greatest need for glutathione supplementation. Diseases like AIDS5, cancer6, asthma7 and Alzheimer’s8 are almost always accompanied with significantly reduced levels of this extremely crucial antioxidant.

But What If I’m Healthy, Do I Still Need Glutathione?

Most likely, you do.

Those unhealthy individuals with low glutathione may be in more urgent need of supplementation to raise the body’s glutathione to more optimal levels.

In healthy people, glutathione deficiency may not be a problem. The body is able to naturally synthesize (produce) its own glutathione using precursors. These precursors are the amino acids L-cysteine, L-glutamic acid, and glycine.

If you are in good health, your body may be making enough glutathione to keep your various systems detoxified and well protected.


Even if you are healthy, there are many other factors that will affect glutathione production. These include genetics, your environment, diet and age.

Under perfect conditions, you wouldn’t need any supplements. Your body’s glutathione production would be enough to stabilize free radicals and eliminate heavy metals and other toxins from the body. But life is rarely perfect. There are chances that one or more factors could be limiting how much glutathione you are able to make without any supplemental assistance. The reason why many healthy people don’t think they need glutathione is because they don’t notice the symptoms when their glutathione levels are dipping.

The symptoms are mild and set in slowly to a point where you get used to feeling tired, getting sick often, having a dull skin and so on. You don’t think it’s a problem.

Although individual results vary, it is not uncommon for those with serious glutathione deficiency to experience noticeable improvements in health and well being almost immediately following starting glutathione treatment. Healthy people frequently also experience moderate changes and improvements but these may take longer to appear or remain unnoticeable.

With time however, taking glutathione can have substantial benefits. It may reduce age related symptoms, boost your immunity, reduce the risk of cancer, increase energy levels or even improve memory among many other potential benefits9.

If you are still unconvinced, here is a look at how certain factors can impact glutathione production even in otherwise healthy people.


Genetics affects everything from how you look to whether you love the taste of specific foods. Genetics also affect your health, determining whether you are at risk of certain inherited diseases and how much glutathione your body is able to make.

When it comes to genetics and glutathione, the GSS gene is the most significant. This gene is responsible for instructing cells to produce glutathione. (  Mutations in the GSS gene can cripple its ability to direct glutathione production in cells. This condition is called glutathione synthetase deficiency. It occurs in three levels: mild, moderate and severe.

While individuals with moderate and severe glutathione synthetase deficiency are at higher risk for more serious health conditions such as seizures and intellectual disability, the mild form of this deficiency does not manifest itself as noticeably.

So you could be generally healthy but still not have enough glutathione in your system to process all the free radicals causing a gradual buildup of oxidative stress. In this scenario you may gradually see an increase in You various symptoms like fatigue, insomnia, or anxiety. And unfortunately due to general aging, most people eventually reach a point where the body’s glutathione production is unable to keep up with its free radical load.

In addition to the GSS gene, a mutation in the MTHFR gene can cause a deficiency in glutathione. This gene is involved in the production of methylene-tetrahydrofolate reductase (MTHFR), an enzyme that plays an indirect role in glutathione production.

Glutathione deficiency is worse if both your parents had mutations in the GSS or MTHFR genes.

The Environment 

Toxins are all around us, from the polluted air you breathe to the sprays you use at home and even the plastics you use. Research has found that environmental toxins play a major role in the occurrence of oxidative stress. They hamper the body’s ability to produce glutathione, causing free radicals to accumulate to toxic levels.

One study showed that people living near busy roads were more likely to develop dementia compared to those living further away10

While pollutants can directly cause health problems, they may also overtax the body’s glutathione reserves, making it difficult to maintain proper cell function which can also contribute to problems like dementia.

So even if you are healthy, where you live could be a big problem. Unfortunately, this is not a factor many people are able to control. You cannot just abandon your career or business and go to the countryside.

In other cases, we get exposed to environmental toxins without being aware. Pesticides, certain utensils, fire retardants, detergents and many other common items may carry toxins that affect glutathione levels11.


All the things you were told to eat when you were a child because they were “good for you” like broccoli, spinach, kale, and the rest of the lot all result in increased glutathione production. There are a variety of other glutathione producing foods that can positively impact the body’s glutathione levels.

Conversely a diet rich in trans fats, carbohydrates, and other conventionally “unhealthy” foods can sap the body’s glutathione reserves creating additional oxidative stress.


Finally, there is the age factor. Over the years, your body continually deteriorates in function. Cells stop working as vigorously as before and various systems lose their vitality.

The aging process also affects glutathione production, reducing it at a rate of around 10% per decade after age 2012 1314.

Glutathione supplementation can mitigate the symptoms of this natural decline in production, assisting in the prevention some of the health problems associated with age related decline of glutathione.

Many people have been surprised at the health improvements they experienced after taking glutathione. We hope you’ll consider supplementing your glutathione levels with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

What is Oxidative Stress and What Can You Do to Prevent It?


Growing up, we are taught about the crucial role oxygen plays on earth. The most important thing we learn is that we cannot breathe without it. Oxygen is life, essentially. A bit later on we also learn that it is important for many processes such as burning and growth.

But did you know that the same life-sustaining oxygen also is the fundamental cause of aging? Oxygen causes oxidation when it combines with certain other elements. This same process can be seen outside the body when steel (iron) rusts or a banana turns brown after being unwrapped and exposed to the air.

Within the body, oxidation is known as oxidative stress and it can also lead to adverse health conditions including cancer1, dementia2, heart failure3 and chronic fatigue syndrome4 among others.

How can such an essential and beneficial substance case all this? The answer is in a scientific term known as Oxidative Stress.

Oxidative stress is the result of certain oxygen byproducts gone rogue. You see, oxygen is used in the body for various processes including metabolism and energy synthesis.

In any chemical process, there have to be byproducts. In addition to releasing mostly harmless byproducts, these oxygen-fueled reactions also release ‘incomplete’ atoms and molecules called free radicals. I say incomplete because they have an unpaired electron.

Hence, they are actively seeking for that electron to complete them. This makes them highly reactive and unstable. They are essentially looking for anything they can react with so as to gain the extra electron and achieve stability.

How Free Radicals Affect the Body and the Body’s Response 

In their quest for stability, free radicals may react with parts of body cells including cell membranes, DNA and proteins. This reaction is known as oxidation. It is the same reaction that causes an exposed apple to turn brown or a piece of metal to rust.

By ‘stealing’ an electron from a cell, a free radical causes damage to that cell, causing it to function defectively. If the damage is extensive, the cell dies.

Now imagine many free radicals attacking many cells in the body. They can cause a lot of havoc. But the body is not without defense. It responds by releasing antioxidants. These are compounds that reduce damage to cells by preventing the formation of free radicals or reacting with them before they can cause damage.

Antioxidants neutralize free radicals by donating one of their electrons without themselves getting unstable. Once stabilized, the free radical is no longer a danger to cells.

How Oxidative Stress Occurs

It is not always that there are enough antioxidants to combat and neutralize free radicals. If the free radicals overwhelm available antioxidants, oxidative stress follows.

This is essentially an imbalance between the number of free radicals and the body’s ability to fend them off using antioxidants. In such a case, free radicals are free to continue their rampage of body cells. As they react with cells and take electrons, they rob crucial components from them. Cell function is severely hampered or completely stopped.

Consequences of Oxidative Stress 

When the body is unable to cope with the number of free radicals, it results in health deterioration as cells lose their vitality and some die.

This can damage major organs such as the kidney, heart and lungs5. It can also affect major functions within the body including digestion and immunity6. Here are some of the possible consequences of oxidative stress.

• Kidney disease7 8.

• Auto immune diseases 9 10.

• Heart disease. This leading killer develops after arteries in the heart harden and narrow in a process called atherosclerosis. A reaction between free radicals and bad cholesterol has been linked to this process. It has been discovered that people who have low antioxidant intake tend to be at the highest risk of heart disease11.

• Joint inflammation leading to conditions such as arthritis12.

• Problems with the digestive system resulting in conditions such as inflammatory bowel disorder13 14.

• Cell damage and death in the brain causes a deterioration of brain health and function. This causes Alzheimer’s, Parkinson’s, Huntington’s disease and other forms of dementia. Oxidative stress has been suggested as one of the main contributors to brain aging15.

• Skin damage. Free radicals can also target skin cells. This compromises major skin functions including UV protection. With continued assault from these reactive molecules, the skin shows accelerated signs of aging. In fact, the Free-radical theory of aging suggests that oxidative stress is the main reason why humans grow old16.

• Apart from causing the skin to age, oxidative stress can also lead to other skin conditions including lesions, scarring and overall skin damage17.

• Cancer. For decades, cancer has stumped researchers with a cure still eluding them. In their study of how it comes about, free radicals have been singled out as major suspects17 18 19. Remember cancer is basically caused by malfunctioning cells. Also remember that free radicals damages cells, affecting how they function. You can see how the two connect.

• Lung disorders. Pollutants in the air can increase the amount of free radicals in the lungs, causing oxidative stress as antioxidants are unable to cope. This could lead to various lung diseases including asthma 20 and lung cancer21.

Symptoms of Oxidative Stress 

There are certain symptoms that signal oxidative stress. They include chronic fatigue4, muscle or joint pain22, memory loss1, unusually early signs of aging such as greyed hair and wrinkles23, decreased eye sight24 as the eye lenses are damaged and increased susceptibility to infections as your immune system is compromised.

Dealing With Oxidative Stress 

Combating oxidative stress is all about returning the balance between free radicals and antioxidants. One way to do this is to make sure the body has access to adequate antioxidants. This involves eating a proper diet with plenty of fruits and vegetables, taking supplements and sleeping well.

Dieting and supplements are especially important as they directly increase the number of antioxidants in the body. Some of the best foods include tomatoes, spinach, walnuts, onions and avocados. These foods supply important antioxidants such as glutathione and vitamin C.

As you add more antioxidants, you also need to take action to prevent excessive formation of free radicals. Avoid junk such as fried food and sugary drinks as they increase oxidation. Avoid spending too much time in polluted areas to protect your lungs from free radicals. Also check the sprays and chemicals you use at home. They could be adding free radicals to your body.

Don’t ignore the importance of a good night’s rest. Poor rest causes an uptick in oxidation, meaning more free radicals are produced to cause even more damage.

Additionally, many health professionals recommend optimizing glutathione levels many individuals have found significant personal benefit in doing so. In order to assist your body in maintaining optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

What are the Different Types of Glutathione Available?


You know the dangers of oxidative stress; how free radicals can damage cells and lead to an assortment of health problems such as cancer and Alzheimer’s1 2. You may also be aware that Glutathione is a powerful natural antioxidant and one of the most effective weapons against oxidative stress3 4 5.

After reading about glutathione and oxidative stress, you may decide you’d like to supplement with glutathione, but you’ll soon discover there are many different forms of Glutathione from oral to Nano Glutathione and even IV drips.

With the large number of supplements and various opinions, studies, and conflicting information, we have assembled a list of the types of glutathione we’re aware of and the pros and cons of each type to assist you in determining which type is best for you.

Nano Sublingual Glutathione

Nano glutathione delivers over 50% of each dose into the blood stream 6 approaching the effectiveness of IV treatment with the convenience of at-home use. Instead of swallowing a capsule, this moderately priced form of Glutathione involves sublingual drops which are placed under the tongue.

The sublingual drops absorb into the blood stream through the mucous membranes in your mouth.


• Over 50% of each dose absorbed into the body 6
• Convenient since you can take it at home.


• Pricier than traditional oral Glutathione (though significantly less expensive than IV Glutathione).

Traditional Oral Glutathione

Oral Glutathione supplements are one of the most popular and oldest Glutathione supplements. They come in capsule, tablet or liquid form.

But traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness. Because they have to pass through the digestive tract, very little of the original dosage survives the acidic stomach environment. What’s left is not enough to significantly increase the amount of intercellular glutathione. Thus no benefits are conferred by these supplements.


• Inexpensive.

• Can be bought over the counter and taken at home.


• Ineffective in increasing Glutathione levels.

Oral Liposomal Glutathione

To counter the disadvantages of traditional oral Glutathione supplements, researchers have come up with a new and better form of oral Glutathione. It is called Liposomal Glutathione.

Though usually taken orally, liposomal Glutathione is able to survive the journey through the gastrointestinal system and safely reach target cells.

How does it do this?

It’s all in how the dosage is transported. To design an effective transportation mechanism, experts borrowed from how substances in the body are transported. The body uses vesicles – a special sac with a fluid in it and surrounded by a fat layer – to transport materials to and from cells. The outer membrane of the vesicle is similar to a cell membrane, making it easy for the two to fuse. The vesicle is able to easily transfer its contents into the cell.

Artificial vesicles, called liposomes, work the same way. Glutathione is carried inside these tiny sacs with a lipid layer on top for protection. They also have a membrane similar to that of a cell. Thus, Liposomal Glutathione can reach target cells while still largely intact unlike traditional oral Glutathione.


• More effective than traditional oral supplements.

• Moderately priced.

• Can be taken at home.


• More expensive than traditional oral Glutathione.

• Only moderately effective raising they body’s Glutathione levels.

• Have a very short shelf life due to the Lipid layer

Acetyl Glutathione

Acetylation is a common process in medicine. It involves the addition of an acetyl group into a chemical compound. In fact, both aspirin and heroin contain acetyl. When added to oral glutathione, acetyl makes it more stable. The supplement can therefore pass through the digestive tract without undergoing the same severe degradation that traditional oral glutathione does.

Research is still ongoing on the effectiveness of Acetyl Glutathione but early studies and anecdotal evidence shows a slight increase in Glutathione levels after taking it.

As with Liposomal Glutathione, Acetyl Glutathione was developed to provide a more effective way to orally take Glutathione supplements.


• Moderately effective.

• Easy and convenient at-home use.


• More expensive than most other oral supplements mostly because of the complex production process.

• Production process requires toxic chemicals that are not natural.

Remember in order to minimize free radical production that a diet rich in fresh fruits and vegetables has been shown to be beneficial. Exercise and rest also can be beneficial. Additionally, you may consider supplementing with glutathione and to ensure optimal levels, we recommend using Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

The Link Between Oxidative Stress and Heart Disease


Most serious human diseases and perhaps even the process of aging can be credited to oxidative stress1 which research has found to play a definite role in the development of such problems as heart disease and conditions relating to blood pressure2. The oxidative stress occurs largely in mitochondria from free radicals (reactive oxygen and reactive nitrogen species). Oxidative stress manifests through lipid metabolism, apoptosis, and formation of atherosclerosis, thrombosis, plaque rupture, fibrosis, myocardial injury, and failure. Recent and continuing research has generated a keen interest of both scientists and the general public in oxidative stress. This has encouraged the use of antioxidants to prevent development of oxidative stress and thus reduce the risk of heart disease which researchers believe to show much promise3.

Introduction to Oxidative Stress

Oxidative stress is better understood as the imbalance between the production of free radicals and antioxidant defenses. Oxidative stress, therefore, means the reduced ability of the body to eliminate toxins presented by free radicals (reactive oxygen species) and a leading to an inability to repair the damage caused by these free radicals. Long-term oxidative stress culminates in an enhanced formation of free radicals and peroxides. This, in turn, diminishes the effectiveness of the body’s natural antioxidant mechanism which is responsible for protecting the body against these free radicals.

The situation described is that in which the amount of glutathione in the body is diminished such that an imbalance begins to exist between the formation of free radicals and the production of antioxidant defenses. As the body’s ability to clear the toxins presented by free radicals is diminished it progressively becomes unable to repair the damage caused by these free radicals. Free radicals may damage and alter some macromolecules in cells, such as Deoxyribonucleic Acid, Ribonucleic Acid, proteins, and lipids. These alterations may develop even stronger reactive species. The effect of oxidation of DNA could be harmful as it may alter transcription and replication of many pervasive serious illnesses that are to blame for a great degree of human suffering.

As the period which the body experiences oxidative stress continues, the accumulation of these free radicals increases. In the long run, the level of free radicals in the body becomes abnormal hence degrading the self-repair system of antioxidant defense. This imbalance creates an upheaval of the normal conditions within the cells of the body.

What is Glutathione?

Glutathione is widely described as the master antioxidant of the human body. This antioxidant is naturally produced in the whole body and is found within all the cells even though its concentration in various parts of the body may differ. The antioxidant is most present in the liver but is in all other organs of the body such as the heart. It is referred to as the master antioxidant as it plays a major part the body’s defense against toxins. These are the toxins which are presented in the body by reactive oxygen species, otherwise known as free radicals.

Glutathione is the body’s natural way of preventing imbalances in the redox state in the body and is therefore tasked with the responsibility of repairing the damage caused by oxidative stress. Furthermore, glutathione attempts to decrease oxidized forms of other antioxidants like alpha-tocopherol and ascorbate in the cells of the body. Consequently, glutathione serves to reduce oxidative stress4 which according to available research plays a big role in the development of heart disease and complications relating to blood pressure5.

Oxidative Stress and Heart Disease

Free radicals, produced by the process of oxidation, are very unstable and extremely reactive. They are therefore highly toxic for tissues such as the heart. Studies performed on isolated perfused hearts have shown that even short-term attacks by oxygen radicals may cause a decline in high-energy phosphates, diminish contractile function and distort the normal structure. Free radicals may also react with unsaturated lipids and set off the process of peroxidation of lipids in the membranes.

Free radicals may also oxidize sulfhydryl groups in proteins and may also facilitate strand scission in nucleic acids. According to initial vivo studies, heart disease and complications relating to blood pressure are, to a large extent, encouraged by the formation of free radicals stimulated by auto-oxidation of catecholamine. These vivo studies have also documented the part played by free radicals in ischemia. It is these vivo studies that created a foundation for numerous further studies relating to the significance of free radicals and hence oxidative stress in the development of cardiomyopathies and heart disease.

What part does glutathione play?

When the body system is operating normally, approximately 5% of the oxygen absorbed by the cell is taken through univalent reduction (oxidation) which results in the formation of free radicals. However, the levels of free radicals in body tissues are regulated by a mechanism of natural antioxidants and free radical destroyers that are generated endogenously throughout the human body. Such antioxidants include the enzymes superoxide dismutase, glutathione peroxidase, and catalase enzyme. Superoxide dismutase is responsible for catalyzing the dismutation of superoxide anion to hydrogen peroxide, while catalase enzyme and glutathione peroxidase act as catalysts for the reduction of hydrogen peroxide to water. Besides, glutathione peroxidase eliminates other hydroperoxides that are produced through reactions of free radicals.

These natural antioxidants of the human body have been found to adapt according to physiological and pathological conditions, such as age, hypertrophy, and exercise. In pathological or disease conditions, like diabetes, high blood pressure, and heart disease among others, the formation of free radicals can supersede the self-repairing mechanism of antioxidants resulting in a situation referred to as oxidative stress.’ Various scientific and clinical research has shown that long-term oxidative stress and diminished antioxidant effectiveness have detrimental impact on the structure and functioning of the heart. Clinical studies on patients with heart disease have also given credence to the significance of free radicals and hence oxidative stress in the development of heart disease. The benefits of antioxidant therapy, such as with glutathione may also have therapeutic Benefits.

Glutathione has been shown to provide health benefits and be supportive in relation to a large number of conditions. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.

Oxidative Stress and Health: Alzheimer’s Disease and Other Brain Conditions


Scientists and the general public have increasingly demonstrated a keen interest in oxidative stress in humans with reliable research linking oxidative stress to a myriad of serious health complications. Such complications are those conditions affecting the brain of which Alzheimer’s is an example. Various research reports have supported this argument with studies highlighting the fact that indeed most patients suffering from Alzheimer’s and other brain conditions are also experiencing long-term oxidative stress1.

Furthermore, molecular biology researchers have put forward that free radicals, which are the primary catalysts of oxidative stress are also involved in the development of Alzheimer’s and other brain conditions. Therefore in as much as the specific cause of Alzheimer’s is yet to be discovered, it is important to strive to reduce oxidative stress as part of treatment for Alzheimer’s and other brain conditions. This new scientific knowledge has led to the increased need for healthier consumption with scientists warning against modern processed foods.

Understanding Alzheimer’s Disease
The most widespread form of dementia, Alzheimer’s is a condition which greatly impairs memory and thinking. The disease is progressive and degrading and occurs in the brain. Dementia is considered a syndrome as it is as a result of a variety of symptoms. These typically include a deterioration of reasoning, communication, memory and judgment, and behavioral and mood changes. Alzheimer’s disease develops slowly, affecting different areas of the brain. As it progresses, different abilities become impaired. Consequently, a person’s behavior and abilities begin to change. The person begins to lose some of his/her abilities.

There exists in every organ of the human body, a natural self-repair system. Alzheimer’s disease and other brain conditions develop when this natural self-repair and self-healing system in the brain becomes overwhelmed. It is this system that is responsible for maintaining the healthy state of the nerve cells. This means that oxidative stress, which is the immediate consequence of such an imbalance, is a major causal factor of Alzheimer’s disease and other brain conditions.

While the symptoms of Alzheimer’s disease develop progressively and may go discovered for a long time, there are a number of factors that if present at the same time may suggest the presence of the disease. These symptoms include language problems, difficulty with abstract reasoning, mood and behavioral changes, diminished judgment, personality adjustments, problems accomplishing well-known tasks, lack of initiative, misplacing items, poor orientation of time or surroundings, and loss of memory resulting in difficulty to undertake daily activities. Each of these symptoms occurring individually or in part, however, does not mean the presence of Alzheimer’s disease. It is important to not assume without testing as these factors may be as a result of other brain conditions.

What is Oxidative Stress?
Oxidative stress describes a situation in which the glutathione levels in the body are reduced such that an imbalance is created between the accumulation of free radicals and the production of antioxidant defenses. Oxidative stress means that the body’s ability to eliminate toxins presented by free radicals is weakened making it incapable of repairing the damage caused by these free radicals. Research has proven that short-term oxidative stress can significantly impact aging through mitohormesis. However, prolonged oxidative stress encourages increased production of these free radicals. Eventually, the accumulated free radicals in the body become too much causing the self-repair system of antioxidant defense to degrade. This causes a distortion in the workings of the cells of the body.

Oxidative Stress and Brain Disease
There exists sufficient scientific evidence of the exposure of Alzheimer’s patients’ brains’ exposure to oxidative stress as the disease progresses. Oxidative stress is presented as a shift in the balance between the body’s antioxidant defense mechanism and the rate of accumulation of free radicals in the body organs such as the brain. These two elements are considered to impact the process of age-associated neuro-degradation majorly and are largely responsible for a decline in those functions of the brain which are related to logic.

The fact that oxidative stress is a part of Alzheimer’s disease is evidenced by high amounts of oxidized proteins, peroxided lipids, and final products of advanced glycation and presence of toxic species. The nuclear and mitochondrial DNA may also be modified. Alzheimer’s and other brain conditions relating to the decline in memory are associated to a weaker system of brain and plasma antioxidants defense.

The oxidative damage suffered by patients of Alzheimer’s disease and other brain conditions is linked to extremely high levels of Amyloid-β and the deposition of neurofibrillary tangles. Available scientific research has shown that bio metals such as zinc, iron and copper which are present in Amyloid-β play a key part in neuro degradation2.

There exists a definite correlation between accumulation of Amyloid-β and oxidative stress. According to scientific evidence, is known to stimulate an increase in the production of reactive oxygen species. Furthermore, Amyloid-β can corrupt mitochondria and this may also further enhance the production of these reactive oxygen species (free radicals). The effects of this increased production and hence abnormal accumulation of free radicals on the brain is manifested through increased lipid peroxidation. As a consequence, the levels of Glutathione and Vitamin E in the body are diminished. Note that glutathione is the body’s primary antioxidant which is produced naturally in all organs including the brain. This evidence was observed through a study of a mouse model whereby a mouse with Alzheimer’s disease was tested. The increased formation of reactive oxygen species has been found to increase dysfunction of mitochondria and this eventually leads to apoptosis3.

The brain generally has high energy output as a result of the activities involved in its functioning. This is associated with a higher production of reactive oxygen species (free radicals) which may subside the ability of the body’s antioxidant mechanism to eliminate the toxins presented by these free radicals. This enhanced accumulation of free radicals and hence oxidative stress is what impairs the cognitive functioning of the brain leading to Alzheimer’s disease and other brain conditions such as front temporal dementia, vascular dementia and dementia with Lewy bodies. In treating Alzheimer’s disease and other brain conditions, it is therefore important to alleviate oxidative stress. However, the genetic factors stimulating oxidative stress are beyond our control. We can seek to consume foods that are considered as more healthy and maintain a generally healthy lifestyle while maintaining optimal levels of glutathione by supplementing with high quality bio-available supplements. In order to maintain optimal glutathione levels, consider supplementing with Nano Gluathione. Click the link below to receive up to 40% on your first purchase.