Symptoms of Detoxification (The Herxheimer Reaction)


Glutathione is the most powerful detoxification agent produced within the human body. When we supplement with glutathione, we can increase the capacity of our body to eliminate toxins, and this can also influence our body to detoxify itself rapidly.

Rapid detoxification can result in some discomfort, which is experienced through a wide range of bodily reactions. This experience of reactions is collectively known as the Herxheimer Reaction (sometimes called a Herx Reaction, or simply Herx). The reaction is typically short lived, from a few days to at most a few weeks. This reaction includes any circumstance where the volume of toxic material exceeds the capacity of the body to eliminate it.

The primary channel of elimination within our bodies is the lymph system, which connects to every cell, working around to clock to dispose of toxins, waste, dangerous bacteria, viruses, or other microorganisms. It’s components include a vast network of vessels, nodes, and organs that circulate lymphatic fluid. This fluid (often referred to as just “lymph”), has a lot in common with blood. But unlike blood, there is no heart to pump and move the lymph. Instead, the body pressurizes the lymph vessels and pumps the fluid through the movement of muscles and joints.

The lymph system is often referred to as the garbage collector of the human body. When garbage fails to be collected or disposed of properly in society, it creates havoc and interrupts the normal flow of life. The same is true for the body. When our bodies cannot eliminate waste fast enough, the lymph system can get backed up, clogging the vessels and disrupting vital bodily functions. This is what generates the Herxheimer Reaction, and it can be experienced through a broad range of symptoms.

If anyone should experience the symptoms of a Herxheimer reaction, please don’t be alarmed. These reactions are signs that the body is hard at work cleansing itself. Some of the uncomfortable symptoms one may experience are outlined below, but they vary from person to person.

  • Headaches
  • Joint Stiffness
  • Muscle Pain
  • Cramps
  • Fatigue
  • Insomnia
  • Hyperactivity
  • Anxiety
  • Irritability
  • Fever
  • Chills or Hot Flashes
  • Bad Breath
  • Excess Bowel Movements
  • Diarrhea
  • Constipation
  • Rashes
  • Acne
  • Abnormal Heart Rate
  • Change in Blood Pressure
  • Hyperventilation
  • Swollen Glands
  • Flu-like Symptoms

The backup of lymph forces the body to take alternative, less ideal actions to remedy the excess waste. This can be helped greatly by taking proactive measures to improve the flow of lymph and reduce the severity of the reaction.

First, if the lymphatic system is overloaded, one can always reduce the amount of Nano Glutathione you are taking. This will give the body a chance to catch up. When the symptoms subside, it is possible to experiment with increasing the dosage.

Second, the lymphatic system relies upon fluidity to move. The liquid for this fluidity is pulled from the water that we drink and the food that we eat, so it is essential to drink lots of water and eat as much as possible in the way of fresh fruits and vegetables.

Third, the lymphatic system relies upon the motion and activity of the body to circulate and eliminate the waste. Exercise will force the lymph to move, and even moderate movement will help. The ideal exercise to move the lymph is a rebounder, which is similar to a trampoline. This up and down motion opens and closes the lymph nodes, and forces the fluid to move through the vessels. That may not be an option for everybody, so simply walking, running, bike-riding, swimming, or any other form of exercise will help the body out. If none of these options are available, then a massage can also be of great benefit. The majority of the lymphatic vessels are close to the surface of the skin, and the fluid can be moved through manual manipulation. This can even be done to oneself if it is not possible to procure a massage.

Fourth, rest is required. The body is working hard to detoxify itself, and this consumes a lot of energy. Paying close attention to the signals the body sends when it needs to rest is essential, along with trying to avoid stress, and performing any available relaxation techniques.

Herxheimer Reactions are typically short-lived. They can last for up to a few weeks, but they are most often resolved within the span of a few days. If you have any serious concerns about any specific reaction you may have after starting to take this product or any other product, you should consult your primary care physician. The information provided is for educational purposes and not intended to be or replace medical advice from your licensed healthcare professional.


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