Why Do I Need Glutathione if I’m Healthy?


Through evolution, the human body has developed a variety of protective measures against the many dangers it faces from things like pathogens and toxins. Glutathione is one of the most impressive guards the body possesses. This potent antioxidant neutralizes dangerous toxins and free radicals in the body1.

Low levels of glutathione in the body have been linked to a decline in health. Conditions such as chronic fatigue2, reduced memory performance3, accelerated aging4 and many others have been linked to low glutathione.

People with certain ailments tend to be at a greater risk of glutathione deficiency and hence have the greatest need for glutathione supplementation. Diseases like AIDS5, cancer6, asthma7 and Alzheimer’s8 are almost always accompanied with significantly reduced levels of this extremely crucial antioxidant.

But What If I’m Healthy, Do I Still Need Glutathione?

Most likely, you do.

Those unhealthy individuals with low glutathione may be in more urgent need of supplementation to raise the body’s glutathione to more optimal levels.

In healthy people, glutathione deficiency may not be a problem. The body is able to naturally synthesize (produce) its own glutathione using precursors. These precursors are the amino acids L-cysteine, L-glutamic acid, and glycine.

If you are in good health, your body may be making enough glutathione to keep your various systems detoxified and well protected.


Even if you are healthy, there are many other factors that will affect glutathione production. These include genetics, your environment, diet and age.

Under perfect conditions, you wouldn’t need any supplements. Your body’s glutathione production would be enough to stabilize free radicals and eliminate heavy metals and other toxins from the body. But life is rarely perfect. There are chances that one or more factors could be limiting how much glutathione you are able to make without any supplemental assistance. The reason why many healthy people don’t think they need glutathione is because they don’t notice the symptoms when their glutathione levels are dipping.

The symptoms are mild and set in slowly to a point where you get used to feeling tired, getting sick often, having a dull skin and so on. You don’t think it’s a problem.

Although individual results vary, it is not uncommon for those with serious glutathione deficiency to experience noticeable improvements in health and well being almost immediately following starting glutathione treatment. Healthy people frequently also experience moderate changes and improvements but these may take longer to appear or remain unnoticeable.

With time however, taking glutathione can have substantial benefits. It may reduce age related symptoms, boost your immunity, reduce the risk of cancer, increase energy levels or even improve memory among many other potential benefits9.

If you are still unconvinced, here is a look at how certain factors can impact glutathione production even in otherwise healthy people.


Genetics affects everything from how you look to whether you love the taste of specific foods. Genetics also affect your health, determining whether you are at risk of certain inherited diseases and how much glutathione your body is able to make.

When it comes to genetics and glutathione, the GSS gene is the most significant. This gene is responsible for instructing cells to produce glutathione. (https://ghr.nlm.nih.gov/gene/GSS#)  Mutations in the GSS gene can cripple its ability to direct glutathione production in cells. This condition is called glutathione synthetase deficiency. It occurs in three levels: mild, moderate and severe.

While individuals with moderate and severe glutathione synthetase deficiency are at higher risk for more serious health conditions such as seizures and intellectual disability, the mild form of this deficiency does not manifest itself as noticeably.

So you could be generally healthy but still not have enough glutathione in your system to process all the free radicals causing a gradual buildup of oxidative stress. In this scenario you may gradually see an increase in You various symptoms like fatigue, insomnia, or anxiety. And unfortunately due to general aging, most people eventually reach a point where the body’s glutathione production is unable to keep up with its free radical load.

In addition to the GSS gene, a mutation in the MTHFR gene can cause a deficiency in glutathione. This gene is involved in the production of methylene-tetrahydrofolate reductase (MTHFR), an enzyme that plays an indirect role in glutathione production.

Glutathione deficiency is worse if both your parents had mutations in the GSS or MTHFR genes.

The Environment 

Toxins are all around us, from the polluted air you breathe to the sprays you use at home and even the plastics you use. Research has found that environmental toxins play a major role in the occurrence of oxidative stress. They hamper the body’s ability to produce glutathione, causing free radicals to accumulate to toxic levels.

One study showed that people living near busy roads were more likely to develop dementia compared to those living further away10

While pollutants can directly cause health problems, they may also overtax the body’s glutathione reserves, making it difficult to maintain proper cell function which can also contribute to problems like dementia.

So even if you are healthy, where you live could be a big problem. Unfortunately, this is not a factor many people are able to control. You cannot just abandon your career or business and go to the countryside.

In other cases, we get exposed to environmental toxins without being aware. Pesticides, certain utensils, fire retardants, detergents and many other common items may carry toxins that affect glutathione levels11.


All the things you were told to eat when you were a child because they were “good for you” like broccoli, spinach, kale, and the rest of the lot all result in increased glutathione production. There are a variety of other glutathione producing foods that can positively impact the body’s glutathione levels.

Conversely a diet rich in trans fats, carbohydrates, and other conventionally “unhealthy” foods can sap the body’s glutathione reserves creating additional oxidative stress.


Finally, there is the age factor. Over the years, your body continually deteriorates in function. Cells stop working as vigorously as before and various systems lose their vitality.

The aging process also affects glutathione production, reducing it at a rate of around 10% per decade after age 2012 1314.

Glutathione supplementation can mitigate the symptoms of this natural decline in production, assisting in the prevention some of the health problems associated with age related decline of glutathione.

Many people have been surprised at the health improvements they experienced after taking glutathione. We hope you’ll consider supplementing your glutathione levels with Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

Staff Writer