What are the Different Types of Glutathione Available?


You know the dangers of oxidative stress; how free radicals can damage cells and lead to an assortment of health problems such as cancer and Alzheimer’s1 2. You may also be aware that Glutathione is a powerful natural antioxidant and one of the most effective weapons against oxidative stress3 4 5.

After reading about glutathione and oxidative stress, you may decide you’d like to supplement with glutathione, but you’ll soon discover there are many different forms of Glutathione from oral to Nano Glutathione and even IV drips.

With the large number of supplements and various opinions, studies, and conflicting information, we have assembled a list of the types of glutathione we’re aware of and the pros and cons of each type to assist you in determining which type is best for you.

Nano Sublingual Glutathione

Nano glutathione delivers over 50% of each dose into the blood stream 6 approaching the effectiveness of IV treatment with the convenience of at-home use. Instead of swallowing a capsule, this moderately priced form of Glutathione involves sublingual drops which are placed under the tongue.

The sublingual drops absorb into the blood stream through the mucous membranes in your mouth.


• Over 50% of each dose absorbed into the body 6
• Convenient since you can take it at home.


• Pricier than traditional oral Glutathione (though significantly less expensive than IV Glutathione).

Traditional Oral Glutathione

Oral Glutathione supplements are one of the most popular and oldest Glutathione supplements. They come in capsule, tablet or liquid form.

But traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness. Because they have to pass through the digestive tract, very little of the original dosage survives the acidic stomach environment. What’s left is not enough to significantly increase the amount of intercellular glutathione. Thus no benefits are conferred by these supplements.


• Inexpensive.

• Can be bought over the counter and taken at home.


• Ineffective in increasing Glutathione levels.

Oral Liposomal Glutathione

To counter the disadvantages of traditional oral Glutathione supplements, researchers have come up with a new and better form of oral Glutathione. It is called Liposomal Glutathione.

Though usually taken orally, liposomal Glutathione is able to survive the journey through the gastrointestinal system and safely reach target cells.

How does it do this?

It’s all in how the dosage is transported. To design an effective transportation mechanism, experts borrowed from how substances in the body are transported. The body uses vesicles – a special sac with a fluid in it and surrounded by a fat layer – to transport materials to and from cells. The outer membrane of the vesicle is similar to a cell membrane, making it easy for the two to fuse. The vesicle is able to easily transfer its contents into the cell.

Artificial vesicles, called liposomes, work the same way. Glutathione is carried inside these tiny sacs with a lipid layer on top for protection. They also have a membrane similar to that of a cell. Thus, Liposomal Glutathione can reach target cells while still largely intact unlike traditional oral Glutathione.


• More effective than traditional oral supplements.

• Moderately priced.

• Can be taken at home.


• More expensive than traditional oral Glutathione.

• Only moderately effective raising they body’s Glutathione levels.

• Have a very short shelf life due to the Lipid layer

Acetyl Glutathione

Acetylation is a common process in medicine. It involves the addition of an acetyl group into a chemical compound. In fact, both aspirin and heroin contain acetyl. When added to oral glutathione, acetyl makes it more stable. The supplement can therefore pass through the digestive tract without undergoing the same severe degradation that traditional oral glutathione does.

Research is still ongoing on the effectiveness of Acetyl Glutathione but early studies and anecdotal evidence shows a slight increase in Glutathione levels after taking it.

As with Liposomal Glutathione, Acetyl Glutathione was developed to provide a more effective way to orally take Glutathione supplements.


• Moderately effective.

• Easy and convenient at-home use.


• More expensive than most other oral supplements mostly because of the complex production process.

• Production process requires toxic chemicals that are not natural.

Remember in order to minimize free radical production that a diet rich in fresh fruits and vegetables has been shown to be beneficial. Exercise and rest also can be beneficial. Additionally, you may consider supplementing with glutathione and to ensure optimal levels, we recommend using Nano Glutathione. Click the link below to receive up to 40% on your first purchase.

Staff Writer